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The objective of the study aims to collect tumor tissue at the moment of progression under Immune checkpoint inhibitors (ICI) in biological resources center in Ambroise Paré hospital, in order to insure later study on molecular mechanism involving the progression of NSCLC and SCLC under ICI.
The further analysis of research will be performed in the EA 4340 unity, Biomarkers and Clinical Trials in cancerology and onco-hematology, UVSQ, University of Paris-Saclay.
The study will consist of creation a tumor tissue bank, all sampling will be stored in the biological resources center of Ambroise Paré hospital.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rebiopsy | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rebiopsy | Procedure | Biopsy will be carry out with flexible bronchoscopy as usual practice under local anesthesia: under endobronchial ultrasound, punction under CT scan or ultrasonography, percutaneous pleural puncturing. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of specific histomolecular resistance | Banking of tumor samples at progression with immune checkpoint inhibitor (ICI) in lung cancer, to evaluate the incidence of specific histomolecular resistance mechanisms to ICI by immunohistochemistry and molecular testing. | At the end of study, up to 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Etienne Giroux Leprieur, MD, PhD | Contact | +33 1 49 09 58 02 | etienne.giroux-leprieur@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Etienne Giroux Leprieur, MD, PhD | Service de Pneumologie et Oncologie thoracique, Hôpital Ambroise Paré, APHP | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Pneumologie et Oncologie thoracique, Hôpital Ambroise Paré, APHP | Recruiting | Boulogne-Billancourt | 92100 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28407528 | Background | Giroux Leprieur E, Dumenil C, Julie C, Giraud V, Dumoulin J, Labrune S, Chinet T. Immunotherapy revolutionises non-small-cell lung cancer therapy: Results, perspectives and new challenges. Eur J Cancer. 2017 Jun;78:16-23. doi: 10.1016/j.ejca.2016.12.041. Epub 2017 Apr 11. |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D018450 | Disease Progression |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |