Efficacy and Safety of Longan Syrup in Healthy Volunteers With Insomnia

Efficacy and Safety of Longan Syrup in Healthy Volunteers With Insomnia

The objectives of this study were to evaluate efficacy and safety of longan syrup in healthy volunteers with insomnia. Subjects will take 15 ml of longan syrup once a day for 3 months. They will be investigated their insomnia using Insomnia Severity Index (ISI) questionnaire, Thai- The Pittsburgh Sleep Quality Index (PSQI) questionnaire,STOP - BANG questionnaire, Epworth Sleepiness Scale (ESS) questionnaire, Actiwatch, plasma cortisol, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), creatinine (Cr), blood urea nitrogen (BUN), fasting blood sugar, HbA1C, complete blood count (CBC), hemoglobin, lipid profile, phosphate level, saliva cortisol, and urine melatonin before and after taken longan syrup.

Inclusion Criteria:

• Age 35-65 years
• Insomnia severity index (ISI) more than 7
• Thai- The Pittsburgh Sleep Quality Index (PSQI)) more than 5
• STOP - BANG less than 5
• No diabetes mellitus and thyroid dysfunction
• Fasting plasma glucose less than 126mg/dl
• Can communication (reading and writing)
• Be willing to be subjects in this study

Exclusion Criteria:

• Know longan allergy or have history of adverse events from longan
• Take benzodiazepine, melatonin, valerian, and St Johns Wort in 1 month before this study starting
• Take medicines, herbs, or food supplements including thiazide diuretics, beta-blockers ,and estrogen that have an effect on blood sugar level in 1 month before this study starting
• Cannot control comorbidity diseases
• Irregular working hours
• Pregnancy or breast feeding
• Participated in other studies