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Inflammatory mediators in periodontitis may lead to elevated systemic cytokine levels, resulting in increased bone resorption including the jaws. Osteoporosis may have an influence on the periodontal condition of post-menopausal women and the risk for periodontal disease may increase due to osteoporosis. The hypothesis of the study was that non-surgical periodontal treatment and medical treatment of osteoporosis by bisphosphonates may improve the clinical outcomes and decrease salivary levels of IL-1β, IL-17, ALP and 8-OHdG. Therefore, the aim of this study was to evaluate the mechanism of bi-directional relationship between osteoporosis and periodontal diseases and to investigate the outcomes of non-surgical periodontal treatment with regard to salivary levels of IL-1β, IL-17, 8-OHdG and ALP in patients with periodontitis and osteoporosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with periodontitis and osteoporosis | Experimental | Group 1 : Patients who have periodontitis and osteoporosis prescribed with bisphosphonates |
|
| Systemically healthy patients with periodontitis | Experimental | Group 2: Patients who have no systemic diseases but diagnosed as periodontitis |
|
| Systemically and periodontally healthy individuals | No Intervention | Group 3: Healthy controls |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| non-surgical periodontal treatment | Procedure | supra- and subgingival scaling, and root planning |
|
| Measure | Description | Time Frame |
|---|---|---|
| salivary levels of IL-1β at baseline | evaluation of the salivary levels of IL-1β in g/ml | baseline |
| salivary levels of IL-1β at 1-month | evaluation of the salivary levels of IL-1β in g/ml | 1-month follow-up after non-surgical periodontal therapy |
| salivary levels of IL-1β at 3-month | evaluation of the salivary levels of IL-1β in g/ml | 3-month follow-up after non-surgical periodontal therapy |
| salivary levels of IL-17 baseline | evaluation of the salivary levels of IL-17 in g/ml | baseline |
| salivary levels of IL-17 at 1-month | evaluation of the salivary levels of IL-17 in g/ml | 1-month follow-up after non-surgical periodontal therapy |
| salivary levels of IL-17 at 3-month | evaluation of the salivary levels of IL-17 in g/ml | 3-month follow-up after non-surgical periodontal therapy |
| salivary levels of alkaline phosphatase at baseline | evaluation of the salivary levels of alkaline phosphatase in g/ml | baseline |
| salivary levels of alkaline phosphatase at 1-month |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque index | Plaque index scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy | baseline, 1- and 3-month follow- up. |
| gingival index | gingival index scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Basak Karasu | Gazi University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gazi University | Ankara | Cankaya | 06500 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
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25 patients with periodontitis (P) and osteoporosis (group 1), 25 systemically healthy patients with P (group 2) and 25 systemically and periodontally healthy individuals (group 3) were enrolled in this study.
Individuals were periodontally examined at baseline, 1 month and 3 months following the non-surgical periodontal therapy.
Participants in group 1 and 2 received non-surgical periodontal therapy including supra- and subgingival scaling, and root planning.Patients were advised and instructed to perform oral care twice a day, use interdental toothbrushes once a day regularly. No scaling and root planning was performed in the group 3.
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evaluation of the salivary levels of alkaline phosphatase in g/ml
| 1-month follow-up after non-surgical periodontal therapy |
| salivary levels of alkaline phosphatase at 3-month | evaluation of the salivary levels of alkaline phosphatase in g/ml | 3-month follow-up after non-surgical periodontal therapy |
| salivary levels of 8-hydroxydeoxyguanosine at baseline | evaluation of the salivary levels of 8-hydroxydeoxyguanosine in g/ml | baseline |
| salivary levels of 8-hydroxydeoxyguanosine at 1-month | evaluation of the salivary levels of 8-hydroxydeoxyguanosine in g/ml | 1-month follow-up after non-surgical periodontal therapy |
| salivary levels of 8-hydroxydeoxyguanosine at 3-month | evaluation of the salivary levels of 8-hydroxydeoxyguanosine in g/ml | 3-month follow-up after non-surgical periodontal therapy |
| baseline, 1- and 3-month follow- up. |
| bleeding on probing | bleeding on probing scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy | baseline, 1- and 3-month follow- up. |
| probing depth | probing depth scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy | baseline, 1- and 3-month follow- up. |
| clinical attachment level | clinical attachment level scores assessed at baseline and at 1 month and 3 months after non-surgical periodontal therapy | baseline, 1- and 3-month follow- up. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |