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High absorption pad for blood and pus with natural antimicrobial agent or gauze dressing impregnated with paraffin, containing 0.5% chlorhexidine acetate (Bactigras) will be randomly covered on half of split-thickness skin graft donor site wound. The another will be cover on another half of split-thickness skin graft donor site wound. Then, they will be covered with gauzes and bandage. Time to wound healing, amounts of covered dressing gauzes, signs of infection, pain score, erythema index, melanin index, trans epidermal water loss index, and adverse events will be evaluated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high absorption pad for blood and pus | Experimental | High absorption pad for blood and pus with natural antimicrobial agent composes of sericin and chitosan. It will be covered on half of split-thickness skin graft donor site wound until the wound has healed. |
|
| commercial wound dressing | Active Comparator | Commercial wound dressing is gauze dressing impregnated with paraffin, containing 0.5% chlorhexidine acetate (Bactigras). It will be covered on half of split-thickness skin graft donor site wound until the wound has healed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high absorption pad for blood and pus | Device | High absorption pad for blood and pus will be covered on half of split-thickness skin graft donor site wound until the wound has healed. |
| Measure | Description | Time Frame |
|---|---|---|
| wound healing time | The day that the dressing will detach without painful. | not more than 28 days |
| amounts of secondary gauze dressing | The amounts of secondary gauze dressing that will be changed because of blood over capacity. | not more than 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| pain score | Pain score will be evaluated using visual analogue scale. The 0 and 10 scores mean no pain and very pain, respectively. Higher score means more painful. | 5 days after donor site wound was created |
| signs of infection |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pornanong Aramwit, Ph.D | Contact | +66899217255 | aramwit@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn Unviersity | Bangkok | 10310 | Thailand |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| commercial wound dressing | Device | Commercial wound dressing will be covered on half of split-thickness skin graft donor site wound until the wound has healed. |
|
Signs of infection mean pain, swollen, red, and warn including pus on the wound.
| not more than 28 days |
| scar melanin index | Scar melanin index will be measured using Cutometer (Mexameter). There is no unit. Higher value mean higher risk of post inflammatory reaction. | 3 months |
| scar erythema index | Scar erythema index will be measured using Cutometer (Mexameter). There is no unit. Higher value mean higher risk of post inflammatory reaction. | 3 months |
| transepidermal water loss index | Transepidermal water loss index of scar will be measured using Cutometer (Tewameter). There is no unit. Higher value mean higher risk of unhealthy scar. | 3 months |
| scar quality | Scar quality will be evaluated using vancouver scar scale. The 0 and 13 scores mean high scar quality and low scar quality , respectively. Higher score means low scar quality. | 3 months |
| adverse events | Adverse events will be observed. They will be recorded as "present" or "not present". | not more than 28 days |
| aspartate aminotransferase in serum | Aspartate aminotransferase in serum (in U/L) after treatment will not be more than before treatment. | not more than 28 days |
| alanine aminotransferase in serum | Alanine aminotransferase in serum (in U/L) after treatment will not be more than before treatment. | not more than 28 days |
| blood urea nitrogen | Blood urea nitrogen (in mg/dl) after treatment will not be more than before treatment. | not more than 28 days |
| serum creatinine | Serum creatinine (in mg/dl) after treatment will not be more than before treatment. | not more than 28 days |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |