Optimal Morphine Dosing Schedule for Neonatal Abstinence Syndrome

Optimal Morphine Dosing Schedule for Neonatal Abstinence Syndrome

Randomized pilot trial comparing scheduled morphine dosing with a weaning protocol to intermittent morphine dosing on an as-needed basis for newborns with neonatal abstinence syndrome.

Inclusion Criteria:

• newborn greater than or equal to 35 weeks gestation
• intrauterine opioid exposure
• signs and symptoms of opioid withdrawal

Exclusion Criteria:

• congenital anomalies or suspected genetic condition
• co-morbid conditions that require sedation or analgesia due to clinical condition
• ongoing need for respiratory support