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This research was planned to determine the level of nesfatin-1, known as satiety hormone, in type 2 diabetes, insulin diabetes and obesity patients and to determine whether there is a relationship between patients' energy intake levels. Additionally, it was aimed to evaluate the relationship between patients' nesfatin-1 values and serum glucose, insulin, lipid concentrations.
Nesfatin-1 levels of patients with type 2 diabetes, insulin resistance and obesity will be measured. In addition, patients' daily food consumption will be taken and the amount of energy they receive will be calculated daily. The relationship between the level of nesfatin-1 in the blood and the energy received will be examined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 2 Diabetes group | Other | In case of fasting, blood will be taken from patients for the measurement of nesfatin-1. |
|
| Insulin resistance group | Other | In case of fasting, blood will be taken from patients for the measurement of nesfatin-1. |
|
| Obesity group | Other | In case of fasting, blood will be taken from patients for the measurement of nesfatin-1. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nesfatin-1 | Diagnostic Test | Blood will be taken from the patients on an empty stomach for measuring nesfatin-1 level |
|
| Measure | Description | Time Frame |
|---|---|---|
| Nefratin-1 in type 2 diabetes | Blood will be drawn from type 2 diabates patients after 12 hours of fasting (n=45) | 1 day (Blood will be drawn from patients once) |
| Nefratin-1 in obesity | Blood will be drawn from obesity patients after 12 hours of fasting (n=45) | 1 day (Blood will be drawn from patients once) |
| Nefratin-1 in insulin resistance | Blood will be drawn from insulin resistance patients after 12 hours of fasting (n=45) | 1 day (Blood will be drawn from patients once) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gülin Öztürk Özkan, Assis Prof | Contact | 02162803333 | glnzturk@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Gülin Öztürk Özkan, Assis Prof | İstanbul Medeniyet University | Study Chair |
| Kadir Kayataş, associate professor | Haydarpaşa Numune Education and Research Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Haydarpaşa Numune Education and Research Hospital | Recruiting | Istanbul | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27754932 | Background | Dore R, Levata L, Lehnert H, Schulz C. Nesfatin-1: functions and physiology of a novel regulatory peptide. J Endocrinol. 2017 Jan;232(1):R45-R65. doi: 10.1530/JOE-16-0361. Epub 2016 Oct 17. | |
| 25470645 | Background | Mirzaei K, Hossein-nezhad A, Keshavarz SA, Koohdani F, Eshraghian MR, Saboor-Yaraghi AA, Hosseini S, Chamari M, Zareei M, Djalali M. Association of nesfatin-1 level with body composition, dietary intake and resting metabolic rate in obese and morbid obese subjects. Diabetes Metab Syndr. 2015 Oct-Dec;9(4):292-8. doi: 10.1016/j.dsx.2014.04.010. Epub 2014 May 25. |
| Label | URL |
|---|---|
| Review | View source |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D007333 | Insulin Resistance |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| 19896982 | Result | Li QC, Wang HY, Chen X, Guan HZ, Jiang ZY. Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans. Regul Pept. 2010 Jan 8;159(1-3):72-7. doi: 10.1016/j.regpep.2009.11.003. |
| Original research | View source |
| Original research | View source |
| D004700 | Endocrine System Diseases |
| D006946 | Hyperinsulinism |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |