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| Name | Class |
|---|---|
| Beijing Chinese Medicine Hospital-Pinggu Hospital | UNKNOWN |
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The purpose of this study is to investigate the effects of dietary supplement with Camel Milk containing Bifidobacterium animalis A6 on the plasma glucose and other related cytokines in patients with type 2 diabetes mellitus. 45 patients with type 2 diabetes mellitus were recruited, and a Double Blind Randomized Parallel Controlled Trial was performed. The fasting glycaemia, 2 hour postprandial glycaemia, insulin, uric acid and serum lipid (total cholesterol, total triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol ) were measured as Primary Outcome. The Fecal microbiome, fecal metabolites, gut hormones (amylin, ghrelin, glucagon-like peptide 1, pancreatic polypeptide), inflammation cytokines (TNF-α, IL-6, MCP-1), myokines (FGF-21, irisin, osteocrin/musclin, osteonectin) and adipokines (adiponectin, resistin, lipocalin-2, adipsin) and body composition analysis were also assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| P | Placebo Comparator | Patients received cow milk for 4 consecutive weeks (two times per day, 10 gram each time). |
|
| CA | Active Comparator | Patients received camel milk with Bifidobacterium animalis A6 at a dose of 2×1010 viable cells for 4 consecutive weeks (two times per day, 10 gram each time). |
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| C | Experimental | Patients received camel milk for 4 consecutive weeks (two times per day, 10 gram each time). |
|
| A | Experimental | Patients received Bifidobacterium animalis A6 at a dose of 2×1010 viable cells for 4 consecutive weeks (two times per day, 10 gram each time). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Camel milk containing Bifidobacterium animalis A6 | Dietary Supplement | Take the interventions about 30 minutes after meals in the morning and evening for 4 consecutive weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in fasting blood glucose and 2 hour postprandial blood glucose in millimole per liter and insulin in μU/mL | follow up the patients at week 0, 4 | 4 weeks |
| Changes in lipid profiles (total cholesterol, total triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in millimole per liter) | follow up the patients at week 0, 4 | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in inflammation cytokines ( TNF-α, IL-6 and MCP-1 in petagram per milliliter) | follow up the patients at week 0, 4 | 4 weeks |
| Changes in fecal microbiome | follow up the patients at week 0, 4 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Chinese Medicine Hospital Pinggu Hospital | Beijing | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 5961288 | Background | Auer HE, Doty P. The synthesis, structure, and optical properties of some copolypeptides containing nonpolar amino acid residues. Biochemistry. 1966 May;5(5):1708-15. doi: 10.1021/bi00869a037. No abstract available. | |
| 17098321 | Result | Agrawal RP, Budania S, Sharma P, Gupta R, Kochar DK, Panwar RB, Sahani MS. Zero prevalence of diabetes in camel milk consuming Raica community of north-west Rajasthan, India. Diabetes Res Clin Pract. 2007 May;76(2):290-6. doi: 10.1016/j.diabres.2006.09.036. Epub 2006 Nov 13. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D008892 | Milk |
| ID | Term |
|---|---|
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D003611 | Dairy Products |
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| Camel milk | Dietary Supplement | Take the interventions about 30 minutes after meals in the morning and evening for 4 consecutive weeks. |
|
| Bifidobacterium animalis A6 | Dietary Supplement | Take the interventions about 30 minutes after meals in the morning and evening for 4 consecutive weeks. |
|
| Cow milk | Dietary Supplement | Take the interventions about 30 minutes after meals in the morning and evening for 4 consecutive weeks. |
|
| 4 weeks |
| Fecal metabolites were identified by GC-MS after extracted with methanol, then oximated with methoxyamine hydrochloride and trimethylsilylated with BSTFA. The concentration was calculated as the area of the peak and normalized to the internal standard. | follow up the patients at week 0, 4 | 4 weeks |
| Changes in body composition (bodyweight in kilograms, height in meters and visceral fat content in square centimeters and body fat in % were measured using the bioelectrical impedance method (BAS-H, SEEHIGHER, Beijing China). ) | follow up the patients at week 0, 4 | 4 weeks |
| Changes in myokines (FGF21, irisin, osteocrin, and osteonectin in petagram per milliliter) and adipokines (adiponectin and adipsin in microgram per milliliter and resistin and lipocalin-2 in petagram per milliliter) | follow up the patients at week 0, 4 | 4 weeks |
| Changes in gut hormones (amylin, ghrelin, GLP-1, PP and PYY in petagram per milliliter) | follow up the patients at week 0, 4 | 4 weeks |
| 5626114 | Result | Saigusa M, Mizuno A, Morimoto K, Nakamura K. [Acute postoperative renal failure due to extracorporeal circulation--with reference to the evaluation of fatal cases]. Kyobu Geka. 1967 Sep;20(9):594-9. No abstract available. Japanese. |
| 5806827 | Result | Casini F, Sbarigia V, Schiavone C. [Identification of Cannabis indica in the residues of incomplete combustion of the drug]. Boll Chim Farm. 1969 May;108(5):330-6. No abstract available. Italian. |
| 5425915 | Result | Baumgarten A, Melrose GJ, Vagg WJ. Continuous recording of dermal exudative reactions. Dermatologica. 1970;140(4):219-24. doi: 10.1159/000252557. No abstract available. |
| 5857053 | Result | Burdon JF. [Medicine in Great Britain]. Concours Med. 1965 Oct 9;87(41):5799-803. No abstract available. French. |
| 6365801 | Result | Lavin MF, Seymour GJ. Reduced levels of fibronectin in ataxia-telangiectasia lymphoblastoid cells. Int J Cancer. 1984 Mar 15;33(3):359-63. doi: 10.1002/ijc.2910330313. |
| D004700 | Endocrine System Diseases |
| D005502 |
| Food |
| D019602 | Food and Beverages |