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The purpose of this study is determine salivary gland disposition of d-limonene, the primary component in citrus peel and a common dietary supplement.
Salivary gland tissue and saliva will be collected to determine concentration of d-limonene and its metabolites in these tissues.
Primary Objective: To determine the bioavailability of Alda-341 in salivary gland tissue.
Secondary Objective: To determine the bioavailability of Alda-341 in saliva and blood
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alda-341 treatment | Experimental | Alda-341 treatment at 2 g/day for 14 days up until the day before regular medical care surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alda-341 | Drug | Dietary supplement d-limonene orally administered as a drug. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Bioavailability of Alda-341 in salivary gland tissue using GCMS | Bio availability of Alda-341 in salivary gland tissue will be measured using gas chromatography mass spectrometry (GCMS). The scale is is 4ng/mL - 8000ng/mL. | 2 week |
| Measure | Description | Time Frame |
|---|---|---|
| Bioavailability of Alda-341 in saliva and blood | Bio availability of Alda-341 in saliva and blood will be measured using gas chromatography mass spectrometry (GCMS). The scale is is 4ng/mL - 8000ng/mL. | 2 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Quynh-Thu Le, MD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Stanford | California | 94304 | United States |
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| ID | Term |
|---|---|
| D013365 | Submandibular Gland Neoplasms |
| D010307 | Parotid Neoplasms |
| ID | Term |
|---|---|
| D012468 | Salivary Gland Neoplasms |
| D009062 | Mouth Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D000077222 | Limonene |
| ID | Term |
|---|---|
| D000081005 | Cyclohexane Monoterpenes |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
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| D009369 |
| Neoplasms |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D012466 | Salivary Gland Diseases |
| D013364 | Submandibular Gland Diseases |
| D010305 | Parotid Diseases |
| D006844 |
| Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D053138 | Cyclohexenes |
| D039821 | Monoterpenes |
| D013729 | Terpenes |