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At present, functional imaging studies have suggested that the Geschwind's territory (the inferior parietal lobe) is an important language area. It is the hub for semantics and phonetic language processing. However, the type and mechanism of aphasia after injury of Geschwind's territory and the subsequent recovery of language are still unclear. In our study based on brain injury model of brain arteriovenous malformation (BAVMs) resection, investigators found that the incidence of aphasia was higher after the injury of Geschwind's territory than after injury of the classical language area, and the type of aphasia was complicated, while the recovery rate of language disorder was high during follow-up. Investigators hypothesized that the type of aphasia may be associated with the type of brain connectivity damaged, and that reorganization of brain connections and brain network promote the recovery of language function. In this study, we aim to investigate the types of aphasia and their corresponding brain network changes after the resection of BAVMs located in the Geschwind's territory. Investigators will evaluate language function and collect multimodality images of the patients before resection of the lesions, as well as 7 days, 3 months and 6 months afterwards. In addition, the anatomical brain connectivity and brain network will also be analyzed. Our research will not only be a meaningful exploration for mechanisms of human language function damage and reorganization, but will also provide an important basis for the protection of brain function in neurosurgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Geschwind's area BAVMs |
| ||
| Healthy controls |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surgical removal of the BAVMs | Procedure | Resection the BAVM nidus by microsurgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Brain network of BAVMs in Geschwind's area | compare the brain network of the Geschwind's area BAVMs patients and normal controls | 2 years |
| Brain network after injury of Geschwind's area | compare the preoperative and postoperative brain network of Geschwind's area BAVMs. | 2 years |
| Brain network of the brain reorganization after surgery | After surgery, we compare the brain network before and after the reorganization. | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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In this study, we will recruit 40 patients with BAVMs located in Geschwind's area, and recruit 40 healthy subjects as healthy control.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yuming Jiao, MD | Contact | 8615010108242 | shengxiongyuming@163.com | |
| Weilun Fu, MD | Contact | 8618611165669 | doctorfwl@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital, Capital Medical University | Recruiting | Beijing | Beijing Municipality | 100070 | China |
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| ID | Term |
|---|---|
| D002538 | Intracranial Arteriovenous Malformations |
| D007802 | Language |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020785 | Central Nervous System Vascular Malformations |
| D009421 | Nervous System Malformations |
| D001165 | Arteriovenous Malformations |
| D054079 | Vascular Malformations |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D020765 | Intracranial Arterial Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003142 | Communication |
| D001519 | Behavior |
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