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This study evaluates the brain and renal oxygenation using near infrared spectroscopy in preterm infants with persistent ductus arteriosus
Patent ductus arteriosus (PDA) is common in preterm infants. In the presence of a large PDA, significant systemic to pulmonary shunting occurs, which may result in pulmonary hyperperfusion and systemic hypoperfusion.
The evidence on PDA effect on brain and renal tissue oxygenation, measured by Near Infrared Spectroscopy is still controversial.
This study aims to evaluate the brain and renal oxygenation using near infrared spectroscopy (NONIN SenSmart model X-100) in 3 groups of preterm infants: 1) closed ductus arteriosus, 2) persistent ductus arteriosus, 3) hemodynamicaly significant ductus arteriosus.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group1 | preterm infant with closed ductus arteriosus, <32 weeks birth weight < 1500g, and > 72 hours of age |
| |
| group2 | preterm infant with PDA < 32 weeks, birth weight < 1500g, and > 72 hours of age |
| |
| group3 | preterm infant with hemodynamically significant PDA < 32 weeks, birth weight < 1500g, and > 72 hours of age |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NONIN SenSmart model X-100 near- infrared spectrometer | Device | for to measure cerebral (cSO2) and renal (rSO2 ) regional tissue oxygen saturation on the day after echocardiography was done. The sensors were placed on the right/left forehead and the right/left lateral posterior flank |
| Measure | Description | Time Frame |
|---|---|---|
| Differences of the mean values of regional oxygenation of the brain and renal | Cerebral and renal regional tissue oxygen saturation monitoring on the day after echocardiography was done | from Day 4 of live up to 36 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Preterm infants with gestation age of < 32 weeks, birth weight < 1500g, > 72 hours of age, will have NIRS monitors placed to measure cerebral and renal regional tissue oxygenation.
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| Name | Affiliation | Role |
|---|---|---|
| Augustina Jankauskiene, MD | Vilnius University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vilnius University Santaros Klinikos Neonatology Center | Vilnius | 08406 | Lithuania |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34886825 | Derived | Navikiene J, Virsilas E, Vankeviciene R, Liubsys A, Jankauskiene A. Brain and renal oxygenation measured by NIRS related to patent ductus arteriosus in preterm infants: a prospective observational study. BMC Pediatr. 2021 Dec 9;21(1):559. doi: 10.1186/s12887-021-03036-w. |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| D004374 | Ductus Arteriosus, Patent |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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|
|
| D000091642 | Urogenital Diseases |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |