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Hirsutism is defined as the excessive presence of terminal hairs in the androgen-sensitive areas of the female body, and it is one of the frequent reasons for presenting to dermatology outpatient clinics. Hirsutism influences 5% to 10% of women around the world and leads to psychological problems depending on ethnic and socio-cultural factors. It also causes material burden including medicines, cosmetic products and epilation procedures.
The differences in the real prevalence of hirsutism in the Turkish population and the hirsutism prevalence and severity between the geographical regions of Turkey are not known. In this study, we aimed to determine the prevalence of hirsutism in women at the reproductive age within Turkey. The geographical regions of Turkey comprise seven regions and and all regions were included in this study. By considering the regions where ethnic differences were high including the east-west-south and north of our country, we aimed to find an answer to the question of whether there were differences in terms of the prevalence and severity of hirsutism among these regions. A comprehensive study aiming to determine the prevalence of hirsutism in Turkey has not been conducted.
Twenty-two provinces of Turkey's seven regions and 26 hospitals from these provinces will be included in the study. The number of samples was specified by the public health specialist on the 2018 census figures. The Turkish population consists of 80,810,525 people according to the data announced by the Turkish Statistical Institute in 2018. In order to determine the prevalence in Turkey, the sample size was calculated with a confidence interval of 99% and error margin of 1%, and the total number of individuals to be screened was designated as 5861. The number of patients to be screened via the clustering method weighted by regions was specified as 1800 for the Marmara Region, 750 for the Aegean Region, 744 for the Mediterranean Region, 568 for the Black Sea Region, 932 for the Central Anatolia Region, 434 for the Eastern Anatolia Region and 633 for the Southeastern Anatolia Region. The provinces that were thought to represent each region were selected via the cluster sampling method.
During the study period, female patients aged between 18 and 45, who present to dermatology outpatient clinics, will be examined clinically until the number of patients designated for each study center is reached, and the hirsutism level of the patients diagnosed with hirsutism will be determined by using the modified Ferriman-Gallwey (mFG) scoring system. In this system, hair growth in nine regions (upper lip, chin, chest, upper back, lower back, upper abdomen, lower abdomen, upper arms and thighs) is graded between 0 and 4. And nine regions are scored between 0 (no terminal hairs) and 4 (excessive presence of terminal hairs). The score above 8 is considered hirsutism. The hirsutism family history, body mass index, menstrual cycle pattern, concomitant disease status (diabetes, hyperlipidemia, hypertension, thyroid disease), history of medication causing body hair growth, the acne presence and severity, presence and severity of androgenic alopecia, presence of seborrhea, presence and localization of acanthosis nigricans, presence of acrochordon, presence of hidradenitis suppurativa, presence of galactorrhea, presence of virilization symptoms and presence of cushingoid symptoms of all the examined patients will be investigated and recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Women with hirsutism | Women between the ages of 18-45 with hirsutism | ||
| Women without hirsutism | Women between the ages of 18-45 without hirsutism |
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| Measure | Description | Time Frame |
|---|---|---|
| Modified Ferriman-Gallwey Scoring System for Severity of Hirsutism | In this system, hair growth in nine regions (upper lip, chin, chest, upper back, lower back, upper abdomen, lower abdomen, upper arms and thighs) is graded between 0 and 4. And nine regions are scored between 0 (no terminal hairs) and 4 (excessive presence of terminal hairs). The score above 8 is considered hirsutism. | 1 day (At the time of the examination) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants With Concomitant disease status and the risk factors | Concomitant disease status (diabetes, hyperlipidemia, hypertension, thyroid disease), hirsutism family history, history of medication causing body hair growth, presence of seborrhea, presence and localization of acanthosis nigricans, presence of acrochordon, presence of hidradenitis suppurativa, presence of galactorrhea, presence of virilization symptoms and presence of cushingoid symptoms of all the examined patients will be determined and recorded. |
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Inclusion Criteria:
Exclusion Criteria:
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During the study period, female patients aged between 18 and 45, who present to dermatology outpatient clinics, will be examined consecutive until the number of patients designated for each study center is reached.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Filiz Cebeci Kahraman, Assoc. Prof. | Contact | +90 537 372 47 22 | cebecifiliz@yahoo.com | |
| Sevil Savas Erdogan, M.D. | Contact | +90 554 261 68 54 | doktorsevilsavas@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Filiz Cebeci Kahraman, Assoc. Prof. | University of Health Sciences, Goztepe Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Adana City Training and Research Hospital | Recruiting | Adana | 01358 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22748844 | Background | Li R, Qiao J, Yang D, Li S, Lu S, Wu X, Wei Z. Epidemiology of hirsutism among women of reproductive age in the community: a simplified scoring system. Eur J Obstet Gynecol Reprod Biol. 2012 Aug;163(2):165-9. doi: 10.1016/j.ejogrb.2012.03.023. Epub 2012 Jun 28. | |
| 30618534 | Background | Lumezi BG, Berisha VL, Pupovci HL, Goci A, Hajrushi AB. Grading of hirsutism based on the Ferriman-Gallwey scoring system in Kosovar women. Postepy Dermatol Alergol. 2018 Dec;35(6):631-635. doi: 10.5114/ada.2018.77615. Epub 2018 Nov 13. |
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| 1 day (At the time of the examination) |
| Body mass indices of the participants | BMI in kg/m^2 | 1 day (At the time of the examination) |
| The presence and severity of acne in the participants | If acne is present, it will be classified as mild, moderate and severe. | 1 day (At the time of the examination) |
| The presence and severity of androgenic alopecia in the participants | If androgenic alopecia is present, it will be classified as Ludwig 1, Ludwig 2, Ludwig 3. | 1 day (At the time of the examination) |
| Menstrual cycle pattern of the participants | The menstrual cycle pattern of the participants will be classified as regular, oligomenorrhea, amenorrhea, polimenorrhea | 1 day (At the time of the examination) |
| School of Medicine, Aksaray University | Recruiting | Aksaray | 68000 | Turkey (Türkiye) |
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| School of Medicine, Ankara Yıldırım Beyazıt University | Recruiting | Ankara | 06010 | Turkey (Türkiye) |
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| School of Medicine, Aydın Adnan Menderes University | Recruiting | Aydin | 09100 | Turkey (Türkiye) |
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| Bitlis Tatvan State Hospital | Recruiting | Bitlis | 13200 | Turkey (Türkiye) |
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| School of Medicine, Uludag University | Recruiting | Bursa | 16285 | Turkey (Türkiye) |
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| University of Health Sciences, Gazi Yasargil Training and Research Hospital | Recruiting | Diyarbakır | 21070 | Turkey (Türkiye) |
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| School of Medicine, Trakya University | Recruiting | Edirne | 22030 | Turkey (Türkiye) |
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| School of Medicine, Eskisehir Osmangazi University | Recruiting | Eskişehir | 26040 | Turkey (Türkiye) |
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| School of Medicine, Gaziantep University | Recruiting | Gaziantep | 27310 | Turkey (Türkiye) |
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| School of Medicine, Süleyman Demirel University | Recruiting | Isparta | 32260 | Turkey (Türkiye) |
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| University of Health Sciences, Bakırköy Sadi Konuk Training and Research Hospital | Recruiting | Istanbul | 34147 | Turkey (Türkiye) |
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| University of Health Sciences, Sultan 2. Abdulhamid Han Training and Research Hospital | Recruiting | Istanbul | 34668 | Turkey (Türkiye) |
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| Istanbul Medeniyet University, Goztepe Research and Training Hospital | Recruiting | Istanbul | 34730 | Turkey (Türkiye) |
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| University of Health Sciences, Umraniye Training and Research Hospital | Recruiting | Istanbul | 34764 | Turkey (Türkiye) |
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| Marmara University Pendik Training and Research Hospital | Recruiting | Istanbul | 34899 | Turkey (Türkiye) |
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| School of Medicine,Izmir Katip Celebi University | Recruiting | Izmir | 35620 | Turkey (Türkiye) |
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| School of Medicine,Kahramanmaras Sutcu Imam University | Recruiting | Kahramanmaraş | 46050 | Turkey (Türkiye) |
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| School of Medicine, Kocaeli University | Recruiting | Kocaeli | 41001 | Turkey (Türkiye) |
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| Meram School of Medicine, Necmettin Erbakan University | Recruiting | Konya | 42090 | Turkey (Türkiye) |
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| School of Medicine, Celal Bayar University | Recruiting | Manisa | 45140 | Turkey (Türkiye) |
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| Sanlıurfa Training and Research Hospital | Recruiting | Sanliurfa | 63300 | Turkey (Türkiye) |
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| School of Medicine, Namık Kemal University | Recruiting | Tekirdağ | 59030 | Turkey (Türkiye) |
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| School of Medicine,Tokat Gaziosmanpasa University | Recruiting | Tokat Province | 60030 | Turkey (Türkiye) |
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| School of Medicine,Karadeniz Technical University | Recruiting | Trabzon | 61080 | Turkey (Türkiye) |
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| University of Health Sciences, Van Training and Research Hospital | Recruiting | Van | 65100 | Turkey (Türkiye) |
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| 23056100 | Background | Fatemi Naeini F, Najafian J, Jazebi N. Hirsutism and body mass index in a representative sample of Iranian people. ARYA Atheroscler. 2012 Spring;8(1):43-54. |
| 9820619 | Background | Carmina E. Prevalence of idiopathic hirsutism. Eur J Endocrinol. 1998 Oct;139(4):421-3. doi: 10.1530/eje.0.1390421. |
| ID | Term |
|---|---|
| D006628 | Hirsutism |
| ID | Term |
|---|---|
| D006201 | Hair Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D014770 | Virilism |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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