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To compare haemodynamics and bispectral index values between conventional bolus propofol induction and target-controlled propofol infusion.
To compare mean arterial pressure, heart rate and bispectral index values between conventional bolus propofol induction and target-controlled propofol infusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional bolus induction | Active Comparator | Hypnotic component of general anesthesia induction will be a single bolus of propofol 2mg/kg followed by turning on sevoflurane 2% at a fresh gas flow of 2L/min. |
|
| Target-controlled induction | Experimental | Hypnotic component of general anesthesia induction will be target-controlled propofol infusion tritiated to loss of consciousness. Propofol target-controlled infusion will be maintained. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol | Drug | 2mg/kg single bolus |
| |
| Propofol Injection [Diprivan] |
| Measure | Description | Time Frame |
|---|---|---|
| Mean arterial pressure after 2 minutes | Mean arterial pressure using non-invasive device | 2 minutes after general anesthesia induction |
| Mean arterial pressure after 4 minutes | Mean arterial pressure using non-invasive device | 4 minutes after general anesthesia induction minutes after general anesthesia induction |
| Mean arterial pressure after 6 minutes | Mean arterial pressure using non-invasive device | 6 minutes after general anesthesia induction minutes after general anesthesia induction |
| Mean arterial pressure after 8 minutes | Mean arterial pressure using non-invasive device | 8 minutes after general anesthesia induction minutes after general anesthesia induction |
| Mean arterial pressure after 10 minutes | Mean arterial pressure using non-invasive device | 10 minutes after general anesthesia induction minutes after general anesthesia induction |
| Measure | Description | Time Frame |
|---|---|---|
| Heart Rate after 2 minutes | Heart rate (pulse rate) using non-invasive device. | 2 minutes after general anesthesia induction |
| Heart Rate after 4 minutes | Heart rate (pulse rate) using non-invasive device. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gabriel MN Guimaraes, MSc | Contact | +5561996455997 | gabrielmng@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Gabriel MN Guimaraes, MSc | Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitário de Brasilia | BrasÃlia | Federal District | 70000000 | Brazil |
Plan to share at open database.
After study ends
Open
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| ID | Term |
|---|---|
| D015742 | Propofol |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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Participant and outcomes Assessor will not know group allocation.
| Drug |
Tritiated Target-Controlled Infusion |
|
| 4 minutes after general anesthesia induction |
| Heart Rate after 6 minutes | Heart rate (pulse rate) using non-invasive device. | 6 minutes after general anesthesia induction |
| Heart Rate after 8 minutes | Heart rate (pulse rate) using non-invasive device. | 8 minutes after general anesthesia induction |
| Heart Rate after 10 minutes | Heart rate (pulse rate) using non-invasive device. | 10 minutes after general anesthesia induction |
| Bispectral Index after 2 minutes | Bispectral Index (BIS) using non-invasive device. At values near 100 mean patient is more likely to be awake and at values below 60 are more likely to be under general anesthesia. | 2 minutes after general anesthesia induction |
| Bispectral Index after 4 minutes | Bispectral Index (BIS) using non-invasive device. At values near 100 mean patient is more likely to be awake and at values below 60 are more likely to be under general anesthesia. | 4 minutes after general anesthesia induction |
| Bispectral Index after 6 minutes | Bispectral Index (BIS) using non-invasive device. At values near 100 mean patient is more likely to be awake and at values below 60 are more likely to be under general anesthesia. | 6 minutes after general anesthesia induction |
| Bispectral Index after 8 minutes | Bispectral Index (BIS) using non-invasive device. At values near 100 mean patient is more likely to be awake and at values below 60 are more likely to be under general anesthesia. | 8 minutes after general anesthesia induction |
| Bispectral Index after 10 minutes | Bispectral Index (BIS) using non-invasive device. At values near 100 mean patient is more likely to be awake and at values below 60 are more likely to be under general anesthesia. | 10 minutes after general anesthesia induction |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |