This study uses single neuron recordings in pre-surgical epilepsy patients to uncover the neural mechanisms underlying memory formation and retrieval. A secondary aim is to improve diagnostic tools to identify epileptogenic tissue.

Inclusion Criteria:

• Interest in participation.
• Temporal lobe epilepsy that is clinically being investigated with implantations of depth electrodes as part of the pre-surgical epilepsy monitoring.
• Cognitive/language skills sufficient to follow experimental instruction and maintain focus on the experiment.

Exclusion Criteria:

• Patient does not want to participate.
• Extra-temporal epilepsy, or electrode implantation strategy that does not allow the use of micro-macrowire electrodes.
• Cognitive/language skills insufficient to follow experimental instruction and maintain focus on the experiment.