Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema

Patients in the Everest area will assessed for evidence of acute HAPE. Subjects will be randomized and assigned to standard care options or treatment with Non-Invasive Positive Pressure Ventilation.

Inclusion Criteria:

• Healthy adults (age 18-80)
• Travel through Pheriche, Nepal
• Diagnosis of HAPE by symptoms, vital signs, and lung ultrasound

Exclusion Criteria:

• History of chronic respiratory conditions (asthma, COPD, ILD)
• Concomitant pneumonia or aspiration, cardiomyopathy, congestive heart failure
• Kidney disease
• Neurologic disorder
• Cognitive disorder
• Temporary altered mental status
• Use of phosphodiesterase inhibitors or nifedipine prior to diagnosis of HAPE
• Age under 18 or over 80
• Pregnancy

No masking will be done, as the CPAP device will be visible to both participants and investigators