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Severe aortic valve stenosis is known to affect heart haemodynamics, endothelial function and body inflammation markers. Our aim is to investigate the weather transcatheter aortic valve implantation in patients with severe aortic stenosis affects heart rate variability, inflammation markers and endothelial function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TAVI group | Consecutive patients undergoing TAVI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Flow mediated vasodilatation | Diagnostic Test | Measurement of brachial artery diameter change before and after limb ischaemia. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of heart rate variability | Change of heart rate variability (HRV) estimated with digital high resolution ECG recording | 3 to 6 months after TAVI |
| Change of laboratory value of endothelial inflammation markers | Laboratory determined numerical changes in endothelial inflammation markers | 3 to 6 months after TAVI |
| Change of flow-mediated filatation (FMD) of the brachial artery | % flow-mediated dilatation | 3 to 6 months after TAVI |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive patients eligible for transfemoral transcatheter aortic valve implantation
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| Name | Affiliation | Role |
|---|---|---|
| Borut Jug, PhD | University Medical Centre Ljubljana | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UMC Ljubljana | Ljubljana | 1000 | Slovenia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25287265 | Result | Horn P, Stern D, Veulemans V, Heiss C, Zeus T, Merx MW, Kelm M, Westenfeld R. Improved endothelial function and decreased levels of endothelium-derived microparticles after transcatheter aortic valve implantation. EuroIntervention. 2015 Apr;10(12):1456-63. doi: 10.4244/EIJY14M10_02. | |
| 39076751 | Derived | Vitez L, Starc V, Jug B, Bunc M. Improved Endothelial and Autonomic Function after Transcatheter Aortic Valve Implantation. Rev Cardiovasc Med. 2023 May 8;24(5):140. doi: 10.31083/j.rcm2405140. eCollection 2023 May. |
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| ID | Term |
|---|---|
| D001024 | Aortic Valve Stenosis |
| ID | Term |
|---|---|
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Blood withdrawal for endothelial inflammation markers detection
| High resolution ECG | Diagnostic Test | Measurement HRV using high resolution ECG |
|
| Blood withdrawal | Diagnostic Test | Measurement of endothelial inflammation markers |
|
| D014694 |
| Ventricular Outflow Obstruction |