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Trial to use GABA mimetic action of midazolam to ameliorate the severe preeclampsia induced neuronal excitotoxicity using middle cerebral artery transcranial doppler resisitive vasculer indices to evaluate . Secondery goal is to study end organ injury
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Midazolam group | Active Comparator | Midazolam group will receive 1 mg intrathecal midazolam once during induction for anethesia |
|
| control group | No Intervention | control group will receive placebo ( 0.5cm of sterile saline |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intrthecl midazolam | Drug | midazolm as as adjuvant in spinal anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measuring Pulsatality index and resistive index of maternal middle cerebral artery | Resistive vasculer indices outcome after intrthecal midazolam injection | 2 months |
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Inclusion Criteria:
Exclusion Criteria:
All cases are ladies with severe preeclampsia
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Elminia university | Recruiting | Cairo | 61511 | Egypt |
All data of primary and secondery outcome measures will be avaliable
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