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| ID | Type | Description | Link |
|---|---|---|---|
| 2019-A01594-53 | Registry Identifier | ID-RCB |
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| Name | Class |
|---|---|
| Imagine Institute | OTHER |
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The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active coeliac patients | Patients with active coeliac disease |
| |
| Treated coeliac patients | Patients with coeliac disease on gluten free diet |
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| Sprue type I | Patients with refractory coeliac disease of type I |
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| Sprue type II | Patients with refractory coeliac disease of type II |
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| Intestinal Lymphoproliferations | Patients with intestinal lymphoproliferations |
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| Non coeliac enteropathies | Patients with non coeliac immune-mediated enteropathy |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sample collection; gastrointestinal biopsy | Genetic | Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage... |
| Measure | Description | Time Frame |
|---|---|---|
| Intestinal Lymphocytes count | Lymphocytes isolation | Baseline |
| DNA sequencing | Targeted Next Generation sequencing | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Patients planned to have blood specimens and possible upper and/or lower digestive endoscopy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Georgia MALAMUT, MD, PhD | Contact | 33 1 58 41 41 76 | georgia.malamut@aphp.fr | |
| Anaïs LEVESCOT, MD, PhD | Contact | 33 1 42 75 42 77 | anais.levescot@inserm.fr |
| Name | Affiliation | Role |
|---|---|---|
| Georgia MALAMUT, MD, PhD | APHP, Université de Paris (Université Paris Descartes) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Henri Mondor | Not yet recruiting | Créteil | 94010 | France |
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| ID | Term |
|---|---|
| D002446 | Celiac Disease |
| C538273 | Autoimmune enteropathy |
| D015212 | Inflammatory Bowel Diseases |
| D000081207 | Primary Immunodeficiency Diseases |
| ID | Term |
|---|---|
| D008286 | Malabsorption Syndromes |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| Patients without neoplastic or inflammatory intestinal disease | Patients without neoplastic or inflammatory intestinal disease |
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| Hôpital Bicêtre | Not yet recruiting | Le Kremlin-Bicêtre | 94270 | France |
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| Hôpital Saint Louis | Not yet recruiting | Paris | 75010 | France |
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| Hôpital Cochin | Recruiting | Paris | 75014 | France |
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| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D005759 | Gastroenteritis |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |