Acute Intermittent Hypoxia in Persons With Multiple Sclerosis

Evaluating the Use of Acute Intermittent Hypoxia to Improve Symptoms in Persons With Multiple Sclerosis

The overall objective of this project is to investigate the effectiveness of Acute Intermittent Hypoxia (AIH), to improve muscle strength and activity level in individuals with relapsing-remitting MS.

Inclusion Criteria:

• Have relapsing-remitting MS
• Volitional ankle plantar flexion strength in at least one leg
• Are relapse free for 30 days
• Patient-Determined Disease Steps scale score between 3 and 5 (3=gait disability to 5=late cane, need cane to walk 25 feet)

Exclusion Criteria:

• Currently taking antispasticity medications,
• Have cardiovascular or respiratory/pulmonary disorders, metabolic dysfunction, or prior diagnoses of obstructive sleep apnea
• Pregnant or nursing women (safety for developing fetus or infant is unknown)
• Cognitive concerns (must be able to consent to study, follow steps)