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| Name | Class |
|---|---|
| Edward Hines Jr. VA Hospital | FED |
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The overall objective of this project is to investigate the effectiveness of Acute Intermittent Hypoxia (AIH), to improve muscle strength and activity level in individuals with relapsing-remitting MS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute Intermittent Hypoxia | Experimental | 1 minute of 9% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 bouts |
|
| Sham Acute Intermittent Hypoxia | Sham Comparator | 1 minute of 21% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 bouts. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intermittent Hypoxia | Other | 1 minute of 9% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 iterations/episodes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Voluntary Ankle Strength | Maximum isometric ankle plantar-flexion and dorsi-flexion torque using a Biodex | 60 minutes post-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Electromyogram activity | Plantar-flexor and Dorsi-flexor electromyogram activity | 60 minutes post-intervention |
| Symbol Digit Modalities Test | The symbol-digit modalities test (SDMT) is a symbol substitution neuropsychological test that examines a person's attention and speed of processing |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shirley Ryan AbilityLab | Chicago | Illinois | 60611 | United States |
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| ID | Term |
|---|---|
| D020529 | Multiple Sclerosis, Relapsing-Remitting |
| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
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| Sham Hypoxia | Other | 1 minute of 21% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 iterations/episodes. |
|
| 60 minutes post-intervention |
| D003711 | Demyelinating Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |