Learning and Executive Function Disorders in Children and Psychosis Risk at Adult-age

Childhood Learning and Executive Function Disorders and Risk of Psychosis in the Adulthood

The primary objective of the study aims to study transition toward schizophrenia in patients with learning disorders, and to compare the risk between patients with specific learning disorders, and patients with complexed learning disorders (by two types: patients with other neuro-developmental disorders including executive function disorders, and patients with anxiety).

As secondary objectives, the study aims to:

• argue the clinical predicted markers (neuropsychological) transition toward psychosis.
• test the feasibility and the acceptability of a early diagnosis for a potential applicable guidance for different referent centers of learning in French territory.
• have a better classification of patients with learning disorders in order to target a prospective primary prevention of risk of psychosis via the questionnaires (AQ of Baron-Cohen: Autism-spectrum quotient auto-questionnaire; Inventory of Beck Anxiety Inventory, auto-questionnaire for panic disorder and general anxiety; Liebowitz Social Anxiety Scale).
• improve identification of the early signs and the early emerging psychological diseases intervention management (schizophrenia).
• Psychic disability: prevent and reduce non-seeking care and accompaniment situations, and risk of rupture of care.
• permitting better care of psychosocial rehabilitation with cognitive evaluation.

This study will be conducted in Centre de référence des troubles du langage et des apprentissages, Hôpital Raymond Poincaré, APHP, in France.

Inclusion Criteria:

• Patients born between 1990 and 2005, have been cared by Dr Schlumberger in 2014 in the center of language and learning disorders at Raymond Poincaré hospital;
• With severe learning disorders: deficiency in school work, need at least one medical appointment and long-term rehabilitation in the center of language and learning disorders at Raymond Poincaré hospital;
• Affiliated to a social protection schema;
• Written informed consent signed.

Exclusion Criteria:

• Absence of learning disorder;
• Intellectual deficiency;
• Epilepsia;
• Patients who will performed follow-up at Chartres city;
• Patients under guardianship or curatorship;
• Foreign patients under AME schema, a medical help from the state in France.