Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation

Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation

This study describes Cefazolin pharmacokinetics variation to target levels during liver transplantation.

Cefazolin is one of the many drugs used in antibiotic prophylaxis during liver transplantation. However there are no study describing its pharmacokinetics during liver transplantation.

Due to the severe pharmacokinetics interactions caused by both prior hepatopathy and surgical techniques we suppose that Cefazolin blood levels are very different from those targeted for antibiotic prophylaxis.

This study aim to describe pharmacokinetics of Cefazolin during liver transplantation in order to adapt antibiotic prophylaxis strategy in case of unadapted measured levels.

Inclusion Criteria:

• Age over 18
• patient undergoing liver transplantation
• receiving Cefazolin as perioperative antibiotic prophylaxis to prevent surgical site infections

Exclusion Criteria:

• pregnant women
• legal protection or protected adults
• ongoing antibiotic treatment before liver transplantation
• patient inability to receive information or express opposition to the study.
• patient refusing participation