In this study we will assess the presence of prolactin hormone in the gingival crevicular fluid , and synovial fluid of patient with rheumatoid arthritis and periodontitis

Inclusion Criteria:

• for first group patients with active rheumatoid arthritis with periodontitis.
• second group , patients with periodontitis and otherwise systemically healthy
• third group, systemically and periodontallly healthy subjects

Exclusion Criteria:

• smokers,
• pregnant or lactating females
• patients taking medications the affects levels of prolactin hormone.
• no periodontal treatment in the past six months

Egyptian patients with active rheumatoid arthritis and periodontitis.