The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney

The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney: A Double Blind Randomized Placebo-controlled Trial

Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction. Nevertheless, these witnessed effects have not been yet translated into the clinical practice.

Inclusion Criteria:

• anuric and oliguric patients
• calculuar ureteral obstruction

Exclusion Criteria:

• anomalous kidney
• bilateral obstructed kidney
• history of recent use of angiotensin receptor blockers or angiotensin-converting enzyme inhibitors
• ASA score of >3