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Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction. Nevertheless, these witnessed effects have not been yet translated into the clinical practice.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Losartan | Active Comparator | to receive the medication Cozaar (Losartan Potassium 25mg "Merck Sharp & Dohme-UK"), |
|
| Placebo | Placebo Comparator | to receive either placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cozaar (Losartan Potassium 25mg) | Drug | Cozaar (Losartan Potassium 25mg) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Renographic glomerular filtration rate of the affected kidney. | assessed by radioisotope renography using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) in ml/min | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Serum creatinine change | assessed by serum creatnine in mg/dl | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ahmed Shokier | Mansoura University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Urology and nephrology center | Al Mansurah | Outside U.S./Canada | 35516 | Egypt |
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| Placebo | Drug | Placebo |
|
| ID | Term |
|---|---|
| D014570 | Urologic Diseases |
| ID | Term |
|---|---|
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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| ID | Term |
|---|---|
| D019808 | Losartan |
| ID | Term |
|---|---|
| D001713 | Biphenyl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D013777 | Tetrazoles |
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