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the investigators conduct a randomized, open-label trial to evaluate and compare the safety and efficacy of Xiyanping injection in patients with 2019-nCoV pneumonia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Xiyanping injection +other drugs | Drug: Xiyanping injection Xiyanping injection: 10-20ml daily, Qd, the maximum daily dose does not exceed 500mg (20mL) Other drugs: Lopinavir tablet or Ritonavir tablet;Alpha-interferon nebulization;Abidor Hydrochloride |
| |
| other drugs | Lopinavir tablet or Ritonavir tablet;Alpha-interferon nebulization;Abidor Hydrochloride |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Xiyanping injection | Drug | Xiyanping injection, 10-20ml daily, Qd, the maximum daily does not exceed 500mg (20mL) + Lopinavir tablet /Ritonavir tablet or Alpha-interferon nebulization or Abidor Hydrochloride, |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical recovery time | From the beginning of study drug use to fever, respiratory rate, blood oxygen saturation to normal and cough relief, and maintained for at least 72 hours or more, calculated in hours | Up to Day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| Complete fever time | From the beginning of research drug use to body temperature <37.3 ℃ (underarm) or mouth temperature ≤37.5 ° C, or anal or ear temperature ≤37.8 ° C, and maintained for 24h or more | Up to Day 14 |
| Cough relief time |
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Inclusion Criteria:
Exclusion Criteria:
-
Subjects who meet any of the following criteria cannot be enrolled:
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Patients diagnosed with new coronary pneumonia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hongzhou Lu, Master | Contact | 021-37990333 | lunliweiyuanhui2009@126.com |
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| ID | Term |
|---|---|
| D061466 | Lopinavir |
| D019438 | Ritonavir |
| ID | Term |
|---|---|
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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routine blood test
| Lopinavir / ritonavir, alpha-interferon nebulization,Abidor Hydrochloride | Drug | Lopinavir / ritonavir tablets, 2 times a day, 2 tablets at a time; alpha-interferon nebulization;Abidor Hydrochloride |
|
Cough score "day + night" from the beginning of study medication to cough ≤ 1 point, and maintained for 24 hours and above
| Up to Day 14 |
| Virus negative time | From the beginning of the study drug to two consecutive times (sampling interval of at least 1 day) | Up to Day 14 |
| Incidence of severe or critical neocoronavirus pneumonia | Defined as the proportion of subjects exacerbated during treatment and meeting the diagnostic criteria for severe or critical neocoronavirus pneumonia | Up to Day 14 |
| D013844 |
| Thiazoles |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D001393 | Azoles |