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Due to funding and Covid-19 pandemic
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| Name | Class |
|---|---|
| The National Pancreas Foundation | OTHER |
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The main causes of acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP) in children are defects in genes that have been associated to pancreatitis. Among these gene defects CFTR gene mutations are commonly found, 34% ARP and 23% CP . Since not every CFTR gene mutations clinically manifest, just identifying these CFTR gene mutations may not help to establish a clear role of this defect in the etiology of the individual ARP/CP. The novel beta-adrenergic sweat secretion test is a very sensitive test to detect small abnormalities in CFTR function in form of a linear gene-function relation. By identifying even mild CFTR defects, in future will help in finding the role of CFTR modulators and providing treatment to these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interventional Arm | Experimental | All patients consented to study will undergo study intervention which is Beta-adrenergic sweat test (Beta sweat test) using evaporimeter. It takes about 60 minutes to complete this test. Once this test is completed, patient will be considered to have completed the study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beta Adrenergic Sweat Test | Combination Product | In Beta Sweat Test - sweat secretion will be stimulated by injecting a series of drugs within the skin surface. Small needles will be used to inject minute amounts of each drug. Before and after each skin injection, the skin will be cleaned using an alcohol swab.
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of CFTR function using the Beta Adrenergic Sweat Secretion Test | CFTR function assessment of patients with acute recurrent or chronic pancreatitis by using Beta adrenergic sweat test. | 60 mins |
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Inclusion Criteria:
Age : 4 years and older
Diagnosis: Acute recurrent pancreatitis or chronic pancreatitis
History: at least one of the following:
Carry one or two CFTR mutations
Borderline sweat chloride levels
Has Family History of CF
Has had positive CF Newborn screening
Exclusion Criteria:
Pregnant females: will be excluded at screening.
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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Evaporimeter TEWL probes, model RG-1
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|
| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |