COPD and Inflammatory Mediators

Comparison of Exercise Training

Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020.

COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversible.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also many others factors such as genetics and cigarette smoking. Cigarettes are harmful and contribute to different extra pulmonary disorders. Although COPD affects lungs some extrapulmonary manifestations are prescribed such as muscle dysfunction, abnormal respiratory muscles and systemic inflammation. Indeed, the systemic inflammation[6, 8] is considered as a key process in the pathogenesis of COPD. It involves different cells and molecules; high levels of circulating of white blood cells, increased plasma c-reactive proteins (CRP), interleukin 6 (Il6) have been reported in.those patients.Likewise, systemic inflammation could worsen the comorbidities (cardiovascular, osteoporosis..) and may lead to the exercise limitation.

Inclusion Criteria:

• COPD diagnosed by pulmonary function testing
• Clinically stable
• Abscence of other obstructive diseases
• Signed written consent

Exclusion Criteria:

• Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions
• cardiovascular diseases.
• Contre-indications to physical therapy
• Acute exacerbations a month before the intervention