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Dexmedetomidine may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of dexmedetomidine. The investigators have therefore performed the present study to measure the effect of dexmedetomidine on the coagulation pathway according to the drug concentration level using a rotational thromboelastometry test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0 ng/ml | Blood specimen which was added 0 ul of dexmedetomidine |
| |
| 0.5 ng/ml | Blood specimen which was added 0.25 ul of dexmedetomidine |
| |
| 1.0 ng/ml | Blood specimen which was added 0.5 ul of dexmedetomidine |
| |
| 1.5 ng/ml | Blood specimen which was added 0.75 ul of dexmedetomidine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0 ul of dexmedetomidine | Drug | Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 ul) using dexmedetomidine |
| Measure | Description | Time Frame |
|---|---|---|
| FIBTEM | Fibrinolytic pathway values of rotational thromboelastometry analysis/ FIBTEM is not an acronym. | During the rotational thromboelastometry analysis/ an average of 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| INTEM | Intrinsic pathway values of rotational thromboelastometry analysis/ INTEM is not an acronym. | During the rotational thromboelastometry analysis/ an average of 1 hour |
| EXTEM | Extrinsic pathway values of rotational thromboelastometry analysis/ EXTEM is not an acronym. |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy volunteers
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| Name | Affiliation | Role |
|---|---|---|
| Hyo-Seok Na, MD., PhD. | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 13620 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34268623 | Derived | Shin HJ, Boo G, Na HS. Effects of dexmedetomidine on blood coagulation: an in vitro study using rotational thromboelastometry. J Anesth. 2021 Oct;35(5):633-637. doi: 10.1007/s00540-021-02969-x. Epub 2021 Jul 15. |
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| ID | Term |
|---|---|
| D001778 | Blood Coagulation Disorders |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| 0.25 ul of dexmedetomidine | Drug | Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.25 ul) using dexmedetomidine |
|
| 0.5 ul of dexmedetomidine | Drug | Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.5 ul) using dexmedetomidine |
|
| 0.75 ul of dexmedetomidine | Drug | Venous blood is taken from 11 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.75 ul) using dexmedetomidine |
|
| During the rotational thromboelastometry analysis/ an average of 1 hour |