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Lactoferrin (Lf) is a mammalian cationic iron binding glycoprotein belonging to the transferrin family which was discovered 70 years ago, and isolated simultaneously from human and bovine milks in 1960. It is widely distributed in all biological fluids and is also expressed by immune cells, which release it under stimulation by pathogens
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| lactoferrin | Active Comparator | Oral bovine lactoferrin (bfl) 100 mg once daily on empty stomach |
|
| ferrous sulfate | Active Comparator | Oral ferrous sulfate 3-6 mg/kg of elemental iron/day in divided doses |
|
| combined | Active Comparator | combined therapy (both lactoferrin and ferrous sulfate) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactoferrin Bovine | Drug | treatment for 30 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| comparison of efficacy of lactoferrin versus ferrous sulfate tharapy in treatment of patients with iron deficiency anemia. | Complete blood count will be done before and after therapy to detect the effect of the therapy on serum hemoglobin(g/d) | 30 days |
| Comparison of efficacy of lactoferrin versus ferrous sulfate tharapy in treatment of patients with iron deficiency anemia. | Total serum iron(ug/d) will be done before and after therapy to detect effect of the therapy on total serum iron level (ug/d) | 30 days |
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Inclusion Criteria:all patients with iron deficiency anemia from 2 to 15 years old
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ahmed Gaber Ahmed | Assiut University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AssuitU | Asyut | Egypt |
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| ID | Term |
|---|---|
| D018798 | Anemia, Iron-Deficiency |
| ID | Term |
|---|---|
| D000747 | Anemia, Hypochromic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| C020748 | ferrous sulfate |
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| Ferrous Sulfate | Drug | treatment for 30 days |
|
|
| D000090463 |
| Iron Deficiencies |
| D019189 | Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |