Discovering the Effect of Venous Insufficiency on Nocturia

Discovering the Effect of Venous Insufficiency on Nocturia: a Prospective, Controlled Trail

With this prospective controlled trial, we hope to obtain more information about the coexistence between venous insufficiency and nocturia.

In our opinion, venous insufficiency (CEAP 2-3a) leads to an increase in fluid accumulation in the lower limbs due to moving around all day. When laying down during nighttime, this fluid is reabsorbed into the systimic fluid pool, leading to an increase in diuresis and thus an increase in nocturnal voiding. Aim of this study is observe difference in nocturnal frequency and urine production before and after surgical treatment of venous insufficiency.

Inclusion Criteria:

• CEAP 2 till 4A

Exclusion Criteria:

• BMI higher than 30
• Previous surgery due to venous insufficiency at the lower limbs
• Cronic edema (Cronic heart failure, liver cirrosis, nefrotic syndrome)
• Pregnant patient
• Patients on the following medication: Calcium-antagonists, lithium, NSAID's or corticosteroids, glitazones, insuline, diuretics, sartans, ACE-inhibitors, desmopressine,