Assessment of Hemostatic Profile in Liver Cirrhosis

Assessment of Hemostatic Profile in Patients With Mild to Advanced Liver Cirrhosis

Our study included both in- and outpatients suffering from liver cirrhosis attending the out- and inpatient care of the department of hepatology. Demographic and biochemical data as well as medical history including cause of liver cirrhosis, end stage kidney failure and medication with anticoagulants were recorded. To assess the hemostatic profile, platelet function was analyzed by multiple electrode aggregometry (MEA) using Multiplate (ADP-, ASPI- and TRAP-test) and thrombelastometry using ROTEM (EXTEM, INTEM, FIBTEM).

Inclusion Criteria:

• liver cirrhosis
• age of ≥ 18 years
• platelet count of at least 70 / nl

Exclusion Criteria:

• transfusion of platelet concentrate three weeks prior to inclusion
• pregnancy
• age < 18 years
• missing informed consent