Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The objective of the study is to determine the incidence of faecal incontinence in prostate cancer survivors treated with moderately hypofractionated radiation therapy and correlate the dose received by the anal sphincter with the degree of faecal incontinence.
The investigators know that high doses of irradiation in the anal sphincter are associated with more chronic fecal leaks in survivors irradiated by normofractionated radiotherapy prostate cancer.
The safe dose of irradiation of the anal sphincter with radiotherapy modern techniques (volumetric modulated arc therapy with moderately hypofracctionation) is unknown.
Urgency and faecal incontinence greatly affects the quality of life of these patients.
Therefore, it is interesting to implement strategies to protect the anatomical structures involved in fecal continence.
The objective of the study is to determine the incidence of faecal incontinence in prostate cancer survivors treated with modern moderately hypofractionated radiation therapy and correlate the dose received by the anal sphincter with the degree of faecal incontinence.
The investigators also want to evaluate the quality of life of these patients
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hypofractionated radiotherapy | Radiation | volumetric modulated moderately fractionated arc therapy |
| Measure | Description | Time Frame |
|---|---|---|
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer patients | before radiotherapy (basal) |
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer survivors | change 2 years after completion of radiotherapy |
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer survivors | change 3 years after completion of radiotherapy |
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer survivors | change 4 years after completion of radiotherapy |
| faecal incontinence after prostate radiation therapy | grade of faecal incontinence in prostate cancer survivors | change 5 years after completion of radiotherapy |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of life after prostate radiation therapy | Quality of life in prostate cancer survivors comparing continents patients and incontinents patients | 3 years after completion of radiotherapy |
| Quality of life after prostate radiation therapy |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Prostate cancer survivors treated in our department by volumetric modulated hypofractionated arc therapy.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Joan Lozano, MD | Consorci Sanitari de Terrassa | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Consorci Sanitari de Terrassa | Terrassa | Catalonia | 08227 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40261490 | Derived | Lozano J, Feltes N, Colomer M, Lizondo M, Carmona M, Romero C, Ribas Y, Paredes S, Galdeano M, Sole JM. Fecal incontinence after moderately hypofractionated volumetric modulated arc therapy for prostate cancer: incidence and impact on quality of life. Clin Transl Oncol. 2025 Oct;27(10):4003-4010. doi: 10.1007/s12094-025-03926-w. Epub 2025 Apr 22. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D004688 | Encopresis |
| D011471 | Prostatic Neoplasms |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001526 | Behavioral Symptoms |
Not provided
Not provided
| ID | Term |
|---|---|
| D000069473 | Radiation Dose Hypofractionation |
| ID | Term |
|---|---|
| D019583 | Dose Fractionation, Radiation |
| D011879 | Radiotherapy Dosage |
| D011878 | Radiotherapy |
| D013812 | Therapeutics |
Not provided
Not provided
Not provided
Not provided
Not provided
Quality of life in prostate cancer survivors comparing continents patients and incontinents patients
| 5 years after completion of radiotherapy |
| D001519 | Behavior |
| D019960 | Elimination Disorders |
| D001523 | Mental Disorders |
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |