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Prospective open-label, non-randomized, monocentric, cohort study, to assess the prevalence and severity of sleep apnea syndrome in patients treated for cancer of the upper aerodigestive tract.
The patient follows a usual course of care including, at the end of the treatment of his cancer of the upper aerodigestive tract, screening for obstructive sleep apnea syndrome at 3 months and 6 months (Epworth score and ventilatory polygraphy)
Prospective open-label, non-randomized, monocentric, cohort study, to assess the prevalence and severity of sleep apnea syndrome in patients treated for cancer of the upper aerodigestive tract.
Patients are included in the study when they are hospitalized for panendoscopy. Thereafter, it takes about 1 month to start any treatment. The duration of treatment is estimated at about 5 months (the longest regimen would be induction chemotherapy followed by surgery and adjuvant complementary treatment). After which the patient follows a usual course of care including, at the end of the treatment of his cancer of the upper aerodigestive tract, screening for obstructive sleep apnea syndrome at 3 months and 6 months (Epworth score and ventilatory polygraphy).
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| Measure | Description | Time Frame |
|---|---|---|
| Occurence of obstructive sleep apnea syndrome | Obstructive sleep apnea syndrome is defined by an apnea-hypopnea index greater than or equal to 15 per hour | 3 months after the end of treatment for cancer of the upper aerodigestive tract |
| Measure | Description | Time Frame |
|---|---|---|
| Delay in onset of obstructive sleep apnea syndrome after completion of cancer treatment | Delay in onset of obstructive sleep apnea syndrome after completion of cancer treatment | during the 6 months follow-up |
| Epworth score |
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Inclusion Criteria:
Exclusion Criteria:
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patients with a recently discovered upper aerodigestive tract tumour who have not yet started treatment
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| Name | Affiliation | Role |
|---|---|---|
| Sandrine Baron, MD | Centre Hospitalier Sud Francilien | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Sud Francilien | Corbeil-Essonnes | 91106 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28543072 | Result | Huyett P, Kim S, Johnson JT, Soose RJ. Obstructive sleep apnea in the irradiated head and neck cancer patient. Laryngoscope. 2017 Nov;127(11):2673-2677. doi: 10.1002/lary.26674. Epub 2017 May 23. | |
| 23575744 | Result | Gilat H, Shpitzer T, Guttman D, Soudry E, Feinmesser R, Bachar G. Obstructive sleep apnea after radial forearm free flap reconstruction of the oral tongue. Laryngoscope. 2013 Dec;123(12):3223-6. doi: 10.1002/lary.24125. Epub 2013 Apr 10. |
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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The Epworth auto-questionnaire, rated from 0 (better) to 24 (worse), assess day-time sleapiness.
| at 3 months and 6 months |
| Occurence of obstructive sleep apnea syndrome | Obstructive sleep apnea syndrome is defined by an apnea-hypopnea index greater than or equal to 15 per hour | 6 months after the end of treatment for cancer of the upper aerodigestive tract |
| 28332763 | Result | Loth A, Michel J, Giorgi R, Santini L, Rey M, Elbaum JM, Roux N, Giovanni A, Dessi P, Fakhry N. Prevalence of obstructive sleep apnoea syndrome following oropharyngeal cancer treatment: A prospective cohort study. Clin Otolaryngol. 2017 Dec;42(6):1281-1288. doi: 10.1111/coa.12869. Epub 2017 Apr 18. |
| 25273079 | Result | Faiz SA, Balachandran D, Hessel AC, Lei X, Beadle BM, William WN Jr, Bashoura L. Sleep-related breathing disorders in patients with tumors in the head and neck region. Oncologist. 2014 Nov;19(11):1200-6. doi: 10.1634/theoncologist.2014-0176. Epub 2014 Oct 1. |