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This is a retrospective cohort study. Patients who underwent liver transplantation from January 1, 2016 to December 31, 2019 were admitted to the study and divided into two groups. Operating room extubation group: early extubation in the operating room immediately following liver transplantation. Intensive care unit (ICU) extubation group: delay extubation in the ICU following liver transplantation. The primary objectives were to compare the incidence of composite outcome between the two groups. secondary objectives were to compare outcomes such as length of stay, hospital length of stay, and total cost between the two groups.
Patients who underwent liver transplantation from January 1, 2016 to December 31, 2019 were admitted to the study. Inclusion criteria: (1) adult patients (age ≥ 18 years), (2) undergoing liver transplantation. Exclusion criteria were the following: (1) re-transplantation; (2) multi-visceral transplantation; (3) intraoperative death; (4) severe encephalopathy (West Haven criteria III or IV); (5) those who had preoperative mechanical ventilation; (6) incomplete clinical data. The primary objectives was a composite of 30-day all-cause mortality, in-hospital AKI, or in-hospital moderate to severe pulmonary complications. Complications were defined and graded as mild, moderate, or severe as described by European Perioperative Clinical Outcome definitions and were included if they occurred in hospital after surgery. The secondary objectives included in-hospital moderate to severe infectious complications, unplanned reintubation rates, ICU and postoperative hospital lengths of stay, and total hospital cost.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Operating room extubation group | extubation in the operating room immediately following liver transplantation |
| |
| ICU extubation group | extubation in the ICU following liver transplantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| extubation in the operating room | Procedure | Patients who underwent liver transplantation early extubation in the operating room immediately following liver transplantation |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of a composite of 30-day all-cause mortality, AKI and moderate to severe pulmonary complications. | Complications were defined and graded as mild, moderate, or severe as described by European Perioperative Clinical Outcome definitions and were included if they occurred in hospital after surgery | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of moderate to severe infectious complications | Complications were defined and graded as mild, moderate, or severe as described by European Perioperative Clinical Outcome definitions and were included if they occurred in hospital after surgery | 30 days |
| The incidence of re-intubation. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who underwent liver transplantation from January 1, 2016 to December 31, 2019 were admitted to the study.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West China Hospital | Chengdu | Sichuan | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34794387 | Derived | Xu Y, Zuo Y, Zhou L, Hao X, Xiao X, Ye M, Bo L, Jiang C, Yang J. Extubation in the operating room results in fewer composite mechanical ventilation-related adverse outcomes in patients after liver transplantation: a retrospective cohort study. BMC Anesthesiol. 2021 Nov 18;21(1):286. doi: 10.1186/s12871-021-01508-1. |
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| ID | Term |
|---|---|
| D060666 | Airway Extubation |
| ID | Term |
|---|---|
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
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| extubation in the ICU | Procedure | Patients who underwent liver transplantation extubation in the ICU following liver transplantation |
|
Reintubation was defined as intubation after extubation of a patient who had been initially tracheal intubated under general anaesthesia |
| 30 days |
| The length of hospital stay | Length of hospital stay is the duration of a single episode of hospitalization | through study completion, an average of 1 year |
| The length of ICU stay | Length of ICU stay is the duration of a single episode of ICU hospitalization | through study completion, an average of 1 year |
| The total hospital cost | The total hospital cost | 30 days |