Analysis of T Cell Metabolism in Acute Myeloid Leukemia Patients

Analysis of T Cell Metabolism and Immune Phenotype During the Course of Acute Myeloid Leukemia

The objective of this study was to analyze the T cell metabolism and immune phenotype in AML patients during the course of the disease before and after allo-HCT.

Patients who experience relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplantation (allo-HCT) have a dismal prognosis. Infusion of donor T cells can induce graft-versus-leukemia (GVL) effects, indicating the importance of intact T cell function for leukemia control. Recent studies have shown the importance of metabolic fitness for an effective T cell response.

In this study we have analyzed the T cell metabolism and immune phenotype in AML patients at different time points before and after allo-HCT.

Inclusion Criteria:

• confirmed diagnosis of AML
• age ≥ 18 years
• peripheral blood sample available
• written informed consent
• ability to understand the nature of the study and the study related procedures and to comply with them

Exclusion Criteria:

• age < 18 years
• lack of informed consent
• patients that cannot be classified in one of the 3 groups