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Assessment of efficacy of primary cyto-reductive surgery in patients with advanced primary epithelial ovarian cancer in Comparison to patients receiving neo-adjuvant chemotherapy (NAC) followed by surgery in complete excision of the tumor reaching R0 without significant morbidity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Active Comparator | 1ry surgery |
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| Group 2 | Active Comparator | Neoadjuvant Chemotherapy followed by surgery |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1ry cyto-reductive surgery | Procedure | 1ry surgery then chemotherapy |
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| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patient where complete resection of the tumor can be achieved | complete resection of the tumor | 3 month postoperative |
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Inclusion Criteria:
Female patients diagnosed with epithelial ovarian cancer (By histopathology)
Age ≥ 18 years old
Advanced defined as (stage 2D or more ) by surgical staging.
Performance status (PS) according to Eastern Cooperative Oncology Group (ECOG) ≤ 2
Chemotherapy naïve
Informed consent
Exclusion Criteria:
Patients previously received chemotherapy or radiotherapy to any part of the abdomen or pelvis.
Patients with uncontrolled infection.
Patients with active bleeding or conditions associated with high risk of bleeding.
contraindications for surgery
contraindications To chemotherapy - bevacizumab
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ali H Ali Sayed, M.Sc | Contact | 02 01061830890 | lolf372@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ali hussien Ali sayed | Recruiting | Asyut | 71111 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40584804 | Derived | Abutaleb H, Hussien A, Khalaf M, Badary DM, Ismail AM, Hassanein S, AlGizawy S, Moustafa SAM, Farghaly RMM, Abdel-Kawi AF. Primary Cytoreductive Surgery Versus Neoadjuvant Chemotherapy Followed by Surgery in Patients with Advanced Primary Epithelial Ovarian Cancer in Low Resources Setting: A Randomized Clinical Trial. J Obstet Gynaecol India. 2025 Jun;75(3):199-205. doi: 10.1007/s13224-024-02061-w. Epub 2024 Nov 6. |
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| ID | Term |
|---|---|
| D020360 | Neoadjuvant Therapy |
| ID | Term |
|---|---|
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
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| Neoadjuvant chemotherapy followed by surgery | Combination Product | chemotherapy then surgery |
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