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| Name | Class |
|---|---|
| Hôpital Edouard Herriot | OTHER |
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Allotransplants of vascularized composite tissues are subject to chronic vascular rejection, which can lead to graft loss. Currently, no imaging technique allows a reproducible quantitative exploration of the arterial trees of the hand, and therefore a satisfactory monitoring of transplants. Since 2014, flow MRI has been applied to the analysis of small-calibre arteries by the Image Processing Team at the Amiens-Picardie University Hospital. Between 2015 and 2017, several acquisitions were made in 3 patients who received facial allotransplantation, and the team recently developed a flow MRI protocol dedicated to the study of arterial trees in the hand.
The main objective is to measure vascular flows of radial, ulnar and interdigital arterial trees in normal (healthy volunteers) and pathological situations (patients with radial forearm flap reconstruction and patients with hand allotransplantation) using the specifically developed flow MRI protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Sham Comparator |
| |
| patients requiring radial forearm flap reconstruction | Active Comparator |
| |
| patients having received hand allotransplantation | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI acquisitions | Other | MRI acquisitions will be performed on the ACHIEVA 3T TX DStream Philips® Research MRI of the GIE Faire Faces. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Variation of radial vascular flows between healthy volunteers and patients with forearm flap reconstruction | Radial vascular flows between healthy volunteers and patients with forearm flap reconstruction will be determined by using the specifically developed flow MRI protocol | day 0 |
| Variation of ulnar artery vascular flows between healthy volunteers and patients with forearm flap reconstruction | Ulnar artery vascular flows between healthy volunteers and patients with forearm flap reconstruction will be determined by using the specifically developed flow MRI protocol | day 0 |
| Variation of interdigital arterial tree vascular flows between healthy volunteers and patients with forearm flap reconstruction | Interdigital arterial tree vascular flows between healthy volunteers and patients with forearm flap reconstruction will be determined by using the specifically developed flow MRI protocol | day 0 |
| Variation of radial vascular flows between healthy volunteers and patients with hand allotransplantation | Radial vascular flows between healthy volunteers and patients with hand allotransplantation will be determined by using the specifically developed flow MRI protocol | day 0 |
| Variation of ulnar artery vascular flows between healthy volunteers and patients with hand allotransplantation | Ulnar artery vascular flows between healthy volunteers and patients with hand allotransplantation will be determined by using the specifically developed flow MRI protocol | day 0 |
| Variation of interdigital arterial tree vascular flows between healthy volunteers and patients with hand allotransplantation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sylvie testelin, Pr | Contact | (33)322089070 | testelin.sylvie@chu-amiens.fr | |
| Bernard Devauchelle, Pr | Contact | (33)322089070 | devauchelle.bernard@chu-amiens.fr |
| Name | Affiliation | Role |
|---|---|---|
| Stéphanie Dakpe, MD | CHU Amiens | Principal Investigator |
| Jérémie Bettoni, MD | CHU Amiens | Principal Investigator |
| Olivier Baledent, MD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens | Recruiting | Amiens | 80480 | France |
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| Doppler ultrasound procedure | Other | The Doppler ultrasound procedure will be conducted in the traditional way in the Vascular Medicine Department of the Amiens-Picardie University Hospital |
|
Interdigital arterial tree vascular flows between healthy volunteers and patients with hand allotransplantation will be determined by using the specifically developed flow MRI protocol |
| day 0 |
| CHU Amiens |
| Principal Investigator |
| Marie-Antoinette Sevestre-Pietri, Pr | CHU Amiens | Principal Investigator |
| Emmanuel Morelon, Pr | Hopital Edouard Herriot | Principal Investigator |
| Palmira Petruzzo, MD | Hopital Edouard Herriot | Principal Investigator |