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| Name | Class |
|---|---|
| University Hospital of Ferrara | OTHER |
| AUSL Romagna Rimini | OTHER |
| Ospedale Morgagni-Pierantoni | UNKNOWN |
| IRCCS Multimedica |
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This is a prospective, observational, multicenter study that enroll consecutive and all-comers patients hospitalized with a diagnosis of Acute Coronary Syndrome (ACS) at admission.
This is a Quality Improvement Program which enroll all the consecutive patients hospitalized with ACS. The data elements that are central to the study include the primary and secondary quality indicators (QIs) that are used to define the performance and to promote improved quality of care.
At least 3000 patients will be enrolled. The primary endpoint are assessed in-hospital, at admission and discharge. Patients will be followed for 1 year after the ACS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with STEACS intended for urgent angio/reperfusion. | This population mostly includes STEACS patients for whom primary PCI is intended. A minority of this population includes patients with STEACS intended for urgent angiography for persistent ST elevation and/or symptoms but with symptoms onset > 12 hours (secondary PCI), urgent angiography after failed fibrinolysis (rescue PCI), or patients receiving fibrinolysis. | ||
| Patients with STEACS NOT intended for urgent angio/reperfusion | This population mostly includes STEACS patients not receiving reperfusion for late presentation (i.e. > 12 hours) or patient preference. Note that patient in this category may receive diagnostic angiography for better diagnostic assessment and/or risk stratification but NOT on an urgent basis. | ||
| Patients with NSTEACS intended for invasive management | This population includes patients with NSTEACS managed invasively with coronary angiography within 72 hours. Most patients are a high-risk feature (i.e. positive troponin, GRACE risk score > 140, hemodynamic/electrical instability) for whom angiography is intended. | ||
| Patients with NSTEACS NOT intended for invasive management | This population includes patients who are candidate for an initially conservative strategy. Note that this category may include patients who are subsequently managed with coronary angiography, including recurring symptoms of myocardial ischemia, or hemodynamic/ electrical instability. |
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| Measure | Description | Time Frame |
|---|---|---|
| Time to reperfusion in patients with STEACS and optimal medical therapy at hospital discharge in patients with a final diagnosis of MI or UA. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| To measure adherence to a wide range of QIs within multiple domains of care including optimal ACS diagnosis, therapy, and individualized risk assessment through monitoring of process of care measures and benchmarked quality-of-care feedback reports. | Baseline | |
| Examine associations of program participation with trends of QIs adherence over 1 year. |
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Inclusion Criteria:
Exclusion Criteria:
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The study is designed to include a consecutive and all-comers population hospitalized with a diagnosis of ACS at admission.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sergio Leonardi, MD | Contact | +39-0382-982105 | s.leonardi@smatteo.pv.it | |
| Monica Portolan, M.Sc. | Contact | +39-0382-982105 | m.portolan@smatteo.pv.it |
| Name | Affiliation | Role |
|---|---|---|
| Sergio Leonardi, MD | Fondazione IRCCS Policlinico San Matteo di Pavia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ferrara University Hospital | Recruiting | Cona | Ferrara | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36124872 | Derived | Leonardi S, Montalto C, Carrara G, Casella G, Grosseto D, Galazzi M, Repetto A, Tua L, Portolan M, Ottani F, Galvani M, Gentile L, Cardelli LS, De Servi S, Antonelli A, De Ferrari GM, Visconti LO, Campo G; ACS Clinical Governance Programme Investigators. Clinical governance of patients with acute coronary syndromes. Eur Heart J Acute Cardiovasc Care. 2022 Nov 30;11(11):797-805. doi: 10.1093/ehjacc/zuac106. | |
| 33372102 |
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| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| D009203 | Myocardial Infarction |
| D000789 | Angina, Unstable |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| OTHER |
| Azienda Usl di Bologna | OTHER_GOV |
| Ospedale Santa Maria delle Croci | OTHER |
| Azienda USL Reggio Emilia - IRCCS | OTHER_GOV |
| ASST Cremona | UNKNOWN |
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| 1 year. |
| To monitor the characteristics, treatments, and outcomes of patients hospitalized with ACS. | Baseline |
| To explore the association between evidence-based acute treatment strategies and risk-adjusted clinical outcomes. | 1 year. |
| To assess utilization of diagnostic imaging, laboratory tests and invasive procedures; and track hospital/coronary care unit length-of-stay data. | Baseline |
| Assess trends in medication dosing patterns, and improve drug safety through targeted quality feedback related to medication overdosing. | Baseline |
| Identify barriers to implementing guideline recommendations for patients with AMI, and develop effective strategies to overcome these barriers | Baseline |
| Ospedale Morgagni-Pierantoni | Recruiting | Forlì | Forlì-Cesena | 47121 | Italy |
|
| IRCCS Multimedica | Recruiting | Sesto San Giovanni | Milano | 20099 | Italy |
|
| Azienda Usl di Bologna | Recruiting | Bologna | 40124 | Italy |
|
| ASST Cremona | Withdrawn | Cremona | 26100 | Italy |
| IRCCS Policlinico S. Matteo | Recruiting | Pavia | 27100 | Italy |
|
| Ospedale Santa Maria delle Croci | Active, not recruiting | Ravenna | 48121 | Italy |
| Arcispedale Santa Maria Nuova | Not yet recruiting | Reggio Emilia | 42123 | Italy |
|
| AUSL Romagna | Recruiting | Rimini | 47924 | Italy |
|
| Derived |
| Leonardi S, Montalto C, Casella G, Grosseto D, Repetto A, Portolan M, Fortuni F, Ottani F, Galvani M, Cardelli LS, De Servi S, Rubboli A, De Ferrari GM, Oltrona Visconti L, Campo G. Clinical governance programme in patients with acute coronary syndrome: design and methodology of a quality improvement initiative. Open Heart. 2020 Dec;7(2):e001415. doi: 10.1136/openhrt-2020-001415. |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D000787 | Angina Pectoris |
| D002637 | Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |