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Myopia is a global healthy concern, especially the high myopia and pathological myopia among Asian populations. However, its mechanism still remains largely unclear. Recent findings suggested choroidal changes might be related to the development of myopia. This study is to useOCT angiography (OCT-A) to investigate parapapillary choroidal microvasculature change in myopic eyes, and try to find the cause-and-effect relationship between choroidal change and the development of myopia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1/Control | Experimental | Spherical equivalent: -2.00~+2.00 D |
|
| Group 1/Myopia | Experimental | Spherical equivalent: -3.00~-6.00 D |
|
| Group 3/High | Experimental | Spherical equivalent: -6.00~-10.00 D |
|
| Group 4/Super High | Experimental | Spherical equivalent: <-10.00 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optic coherence tomography angiography (OCTA) | Device | Using non-invasive, repeatable, mature device OCTA to obtain choroidal angio-map |
|
| Measure | Description | Time Frame |
|---|---|---|
| Parapapillary choroidal microvasculature void (MvV) area | area of parapapillary choroidal microvasculature void on OCTA images | changes of MvV area from at 10 years |
| Parapapillary choroidal microvasculature void (MvV) area | area of parapapillary choroidal microvasculature void on OCTA images | difference of MvV area in each group at baseline |
| Parapapillary choroidal microvasculature void (MvV) area | area of parapapillary choroidal microvasculature void on OCTA images | changes of MvV area at 1 years |
| Parapapillary choroidal microvasculature void (MvV) area | area of parapapillary choroidal microvasculature void on OCTA images | changes of MvV area at 3 years |
| Parapapillary choroidal microvasculature void (MvV) area | area of parapapillary choroidal microvasculature void on OCTA images | changes of MvV area at 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| MvV number | number of choroidal MvV with certain size | baseline |
| Correlation coefficient between choroidal MvV and refractive power | Correlation coefficient between choroidal MvV and refractive power |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zizong Hu, PhD, MD | Contact | +8615195960100 | huzizhong@njum.edu.cn | |
| Qinghuai Liu, PhD, MD | Contact | +8615195960100 | liuqh@njmu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Nanjing Medical University | Nanjing | Jiangsu | 210029 | China |
After completion of the prospective observational study, we would like to share data for reasonable request from other researchers.
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| ID | Term |
|---|---|
| D047728 | Myopia, Degenerative |
| D015862 | Choroid Diseases |
| D009216 | Myopia |
| ID | Term |
|---|---|
| D012030 | Refractive Errors |
| D005128 | Eye Diseases |
| D014603 | Uveal Diseases |
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| baseline |
| Correlation coefficient between choroidal MvV and PPA area | Correlation coefficient between choroidal MvV and parapapillary atrophy beta area | baseline |
| Correlation coefficient between choroidal MvV and choroid thickness | Correlation coefficient between choroidal MvV and choroid thickness | baseline |
| Correlation coefficient between choroidal MvV and RNFL thickness | Correlation coefficient between choroidal MvV and RNFL thickness | baseline |
| Correlation coefficient between choroidal MvV and Axial length | Correlation coefficient between choroidal MvV and Axial length | baseline |
| Correlation coefficient between choroidal MvV and retinal parapapillary perfusion | Correlation coefficient between choroidal MvV and retinal parapapillary perfusion on OCTA images. | baseline |
| Correlation coefficient between choroidal MvV and Macular perfusion | Correlation coefficient between choroidal MvV and Macular perfusion on OCTA images, Retinal parapapillary perfusion with OCTA. | baseline |