Effect of Transcutaneous Electrical Nerve Stimulation in Diabetic Neuropathy

Effect of Transcutaneous Electrical Nerve Stimulation on Pain percepción and Serum Inflammatory Markers in Patients With Peripheral Diabetic Neuropathy

Double-blind, randomized, placebo-controlled, clinical trial. Patients with diabetic neuropathy will be randomly assigned to treatment with either TENS or TENS sham three times a week during 90 days. Clinical determinations are: pain, levesls of TNF-alpha, IL-6 and RPC-us

Inclusion Criteria:

• Diagnostic of type 2 diabetes > 10 years
• Diagnostic of peripheral diabetic neuropathy less than 5 years
• HbA1C > 6.5 and < 9%
• Plasmatic glucose >140 mg/dL and lees than 350 mg/dL
• Informed consent signed

Exclusion Criteria:

• Use of implanted pacemaker or heart defibrillator
• Implanted brain stimulator
• History of alcohol abuse
• Use of NSAID, stereoids
• Subjects with wounds, ulcers in legs
• Subjects with hepatic, renal o neurologic diseases