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This study characterizes the changes in corticospinal excitability that accompany basic cold stress via skin cooling that result in reduced skin or core temperature and shivering.
Cold stress is known to impair both fine and gross motor movement. Reductions in performance may have life threatening consequences in survival situations where maintenance of muscle control is necessary. Much of the effects cooling has on muscle performance is directly due to its effects on muscle tissue itself, whereas less is known about the effects on the central nervous system. Therefore, the purpose of the study was to characterize corticospinal excitability that accompanies basic cold stress via progressive skin cooling, resulting in reductions in skin (Tsk) or core (Tco) temperature and shivering.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Condition | No Intervention | Subjects will sit at rest wearing a liquid perfused suit containing thermoneutral water for 60 min. The suit will not be turned on during this period. | |
| Cold Condition | Experimental | Subjects will be cooled for 60-90 min at ~ 4-10°C using a liquid perfused suit. Subjects will then be rewarmed for 30 min at ~ 41°C using the liquid perfused suit. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cold Stress | Other | 60-90 mins of cooling via a liquid perfused suit circulating ~4-10°C liquid. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Corticospinal Excitability | Motor Evoked Potentials (MEP) as a percentage of the maximal compound muscle action potential (Mmax) measured via MEG at the Biceps Brachii will serve as the indices of Corticospinal excitbaility | at 0, 20, 40, 60 and 90 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Spinal Excitability | Cervicomedullary Motor Evoked Potentials (CMEP) as a percentage of the maximal compound muscle action potential (Mmax) measured via MEG at the Biceps Brachii will serve as the indices of spinal excitability | at 0, 20, 40, 60 and 90 minutes |
| Change in Skin Temperature |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Peripheral nerve excitability | Excitability of the peripheral nerve measured via EMG at the biceps brachia ( the maximal compound motor action potential (Mmax). | at 0, 20, 40, 60 and 90 minutes |
| Change in Maximal Voluntary Contraction of Elbow Flexors |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gordon Giesbrecht, PhD | University of Manitoba | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 211 Max Bell Centre, University of Manitoba | Winnipeg | Manitoba | R3T 2N2 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34582724 | Derived | Hurrie DMG, Talebian Nia M, Power K, Stecina K, Gardiner P, Lockyer E, Giesbrecht GG. Spinal and corticospinal excitability in response to reductions in skin and core temperatures via whole-body cooling. Appl Physiol Nutr Metab. 2022 Feb;47(2):195-205. doi: 10.1139/apnm-2021-0370. Epub 2021 Sep 28. |
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| ID | Term |
|---|---|
| D058639 | Cold-Shock Response |
| ID | Term |
|---|---|
| D013312 | Stress, Physiological |
| D010829 | Physiological Phenomena |
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Repeat Measures
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Mean skin temperature of 7 sites |
| at 0, 20, 40, 60 and 90 minutes |
| Change in Core Temperature | Esophageal temperature is the most accurate method representing the temperature of the heart. | at 0, 20, 40, 60 and 90 minutes |
| Change in Metabolic Heat Production | Metabolic heat production serves as an objective way to quantify shivering thermogenesis. | at 0, 20, 40, 60 and 90 minutes |
Maximal Isometric Force of elbow flexors measured in kg of force |
| at 0, 20, 40, 60 and 90 minutes |