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| Name | Class |
|---|---|
| KU Leuven | OTHER |
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This prospective study will research the exposure and its variability to fluconazole after longitudinal administration in critically ill patients
An open label, monocenter pharmacokinetic study will be carried out in critically ill patients, admitted at the University Hospitals Leuven, receiving multiple dose treatment with fluconazole.
The exposure to fluconazole in the ICU cohort over multiple days of treatment will be documented. Moreover, variability and the correlating covariates that can influence the fluconazole concentration, will be determined.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sample collection | Other | Plasma and urine sample collection |
| Measure | Description | Time Frame |
|---|---|---|
| Exposure to fluconazole (trough levels) | To document the trough levels (Cmin) of fluconazole in an ICU cohort over multiple days of treatment | On the day of sampling |
| Exposure to fluconazole (trough levels) | Determine if the Cmin target levels are attained. | June 2020 |
| Measure | Description | Time Frame |
|---|---|---|
| Variability in fluconazole trough levels | To determine the intra-and intersubject variability of the fluconazole trough levels | June 2020 |
| Influencing covariates | Determine possible covariates that might explain the fluconazole variability |
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Inclusion Criteria:
Exclusion Criteria:
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Critically ill patients.
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| Name | Affiliation | Role |
|---|---|---|
| Isabel Spriet, PharmD, PhD | UZ Leuven | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UZ Leuven | Leuven | 3000 | Belgium |
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| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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Blood and urine
| June 2020 |