Therapeutic Drug Monitoring of Fluconazole in Critically Ill Patients

Therapeutic Drug Monitoring of Fluconazole in Critically Ill Patients: a Longitudinal Follow-up of Trough Levels

This prospective study will research the exposure and its variability to fluconazole after longitudinal administration in critically ill patients

An open label, monocenter pharmacokinetic study will be carried out in critically ill patients, admitted at the University Hospitals Leuven, receiving multiple dose treatment with fluconazole.

The exposure to fluconazole in the ICU cohort over multiple days of treatment will be documented. Moreover, variability and the correlating covariates that can influence the fluconazole concentration, will be determined.

Inclusion Criteria:

• > 18 years
• Treatment with fluconazole
• Admitted to an ICU ward

Exclusion Criteria:

• < 18 years
• DNR 2 or 3