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This research study, conducted by Truth Initiative, will help us learn how text messaging can help young adults between 18 and 24 years of age quit vaping.
The Quit Vaping Study (QVS)'s primary aim is to conduct a fully powered comparative effectiveness trial to evaluate the effectiveness of a quit vaping text message program in promoting abstinence from e-cigarettes among young users aged 18-24. This study is a 2-arm randomized controlled trial conducted among young users aged 18-24 recruited through online channels. Participants will be randomized to a quit vaping text message intervention or to an assessment-only control condition and followed for 7 months to roughly correspond to 6-months post-treatment. The secondary aim is to examine potential mediators of program effectiveness, including treatment engagement and changes in self-efficacy and perceived social support for quitting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| This is Quitting | Experimental | Participants will be enrolled to receive messages from This is Quitting. Users receive one age-appropriate message per day tailored to their enrollment date or quit date, which can be set and reset via text message. Those not ready to quit receive 4 weeks of messages focused on building skills and confidence. Users who set a quit date receive messages for a week preceding it and 8 weeks afterward that include encouragement and support, skill- and self-efficacy building exercises, coping strategies, and information about the risks of vaping, benefits of quitting, and cutting down to quit. Keywords COPE, STRESS, SLIP, and MORE provide on-demand support. |
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| Assessment only Control | Other | After an initial enrollment message, participants will be contacted periodically to assess e-cigarette use. At the end of the intervention period, they will receive information on how to sign up for This is Quitting if they are interested in the program |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| This is Quitting | Other | Text message-based intervention for quit vaping support. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants With Self-reported 30-day Point Prevalence Abstinence (ITT) | Number of participant who responded "No" to the question "In the past 30 days, did you vape at all, even a puff of someone else's?" Denominator is all randomized participants. | 7 months post enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants With Self-reported 30-day Point Prevalence Abstinence (Responder Only) | Number of participants with who responded 'No" to the question "In the past 30 days, did you vape at all, even a puff of someone else's?" Denominator is participants with responses only. | 7 month post enrollment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Amanda L Graham, PhD | Truth Initiative | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Truth Initiative | Washington D.C. | District of Columbia | 20001 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32356774 | Background | Graham AL, Jacobs MA, Amato MS, Cha S, Bottcher MM, Papandonatos GD. Effectiveness of a Quit Vaping Text Message Program in Promoting Abstinence Among Young Adult E-Cigarette Users: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2020 May 1;9(5):e18327. doi: 10.2196/18327. | |
| 35777699 | Background |
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IPD are not available to other researchers. For access to deidentified dataset, please contact study administrator for more information.
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Recruitment conducted from December 29, 2019 and March 18, 2020. Recruitment occurred online using advertisements on social media platforms.
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| ID | Title | Description |
|---|---|---|
| FG000 | This is Quitting | Participants will be enrolled to receive messages from This is Quitting. Users receive one age-appropriate message per day tailored to their enrollment date or quit date, which can be set and reset via text message. Those not ready to quit receive 4 weeks of messages focused on building skills and confidence. Users who set a quit date receive messages for a week preceding it and 8 weeks afterward that include encouragement and support, skill- and self-efficacy building exercises, coping strategies, and information about the risks of vaping, benefits of quitting, and cutting down to quit. Keywords COPE, STRESS, SLIP, and MORE provide on-demand support. This is Quitting: Text message-based intervention for quit vaping support. |
| FG001 | Assessment Only Control | After an initial enrollment message, participants will be contacted periodically to assess e-cigarette use. At the end of the intervention period, they will receive information on how to sign up for This is Quitting if they are interested in the program Assessment only Control: Assessment only |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | This is Quitting | Participants will be enrolled to receive messages from This is Quitting. Users receive one age-appropriate message per day tailored to their enrollment date or quit date, which can be set and reset via text message. Those not ready to quit receive 4 weeks of messages focused on building skills and confidence. Users who set a quit date receive messages for a week preceding it and 8 weeks afterward that include encouragement and support, skill- and self-efficacy building exercises, coping strategies, and information about the risks of vaping, benefits of quitting, and cutting down to quit. Keywords COPE, STRESS, SLIP, and MORE provide on-demand support. This is Quitting: Text message-based intervention for quit vaping support. |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Number of Participants With Self-reported 30-day Point Prevalence Abstinence (ITT) | Number of participant who responded "No" to the question "In the past 30 days, did you vape at all, even a puff of someone else's?" Denominator is all randomized participants. | All randomized participants (Intent-to-treat analysis) | Posted | Count of Participants | Participants | 7 months post enrollment |
|
Entire study duration (7-month participation)
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | This is Quitting | Participants will be enrolled to receive messages from This is Quitting. Users receive one age-appropriate message per day tailored to their enrollment date or quit date, which can be set and reset via text message. Those not ready to quit receive 4 weeks of messages focused on building skills and confidence. Users who set a quit date receive messages for a week preceding it and 8 weeks afterward that include encouragement and support, skill- and self-efficacy building exercises, coping strategies, and information about the risks of vaping, benefits of quitting, and cutting down to quit. Keywords COPE, STRESS, SLIP, and MORE provide on-demand support. This is Quitting: Text message-based intervention for quit vaping support. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Amanda L. Graham, PhD, Principal Investigator | Truth Initiative | (202) 525-6473‬ | vapestudy@truthinitiative.org |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | May 28, 2020 | May 17, 2022 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D020340 | Tobacco Use Cessation |
| ID | Term |
|---|---|
| D015438 | Health Behavior |
| D001519 | Behavior |
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Arm 1: Intervention - Text message intervention Arm 2: Control - Assessment only
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Participants are not explicitly told they are in the control group, although they may deduce their assignment from presence or lack of regular text message intervention.
| Assessment only Control |
| Other |
Assessment only |
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| Number of Participants With Self-reported 7-day Point Prevalence Abstinence (ITT) |
Number of participants who responded "No" to the question "Have you used any vape, even one puff, in the past 7 days?" Denominator is all randomized participants. |
| 7 months post enrollment |
| Number of Participants With Self-reported 7-day Point Prevalence Abstinence (Responder Only) | Number of participants who responded "No" to the question "Have you used any vape, even one puff, in the past 7 days?" Denominator is those who responded to the question only. | 7 months post enrollment |
| Graham AL, Cha S, Papandonatos GD, Amato MS, Jacobs MA, Abroms LC, Berg CJ. E-cigarette and combusted tobacco abstinence among young adults: Secondary analyses from a U.S.-based randomized controlled trial of vaping cessation. Prev Med. 2022 Dec;165(Pt B):107119. doi: 10.1016/j.ypmed.2022.107119. Epub 2022 Jun 28. |
| 33999133 | Result | Graham AL, Amato MS, Cha S, Jacobs MA, Bottcher MM, Papandonatos GD. Effectiveness of a Vaping Cessation Text Message Program Among Young Adult e-Cigarette Users: A Randomized Clinical Trial. JAMA Intern Med. 2021 Jul 1;181(7):923-930. doi: 10.1001/jamainternmed.2021.1793. |
| 41177894 | Derived | Graham AL, Cha S, Do EK, Jacobs MA, Edwards G, Papandonatos GD. Dual abstinence from nicotine vaping and cannabis use among young people: secondary analyses from two U.S.-based randomized controlled trials of vaping cessation. Subst Abuse Treat Prev Policy. 2025 Nov 3;20(1):48. doi: 10.1186/s13011-025-00679-1. |
| BG001 | Assessment Only Control | After an initial enrollment message, participants will be contacted periodically to assess e-cigarette use. At the end of the intervention period, they will receive information on how to sign up for This is Quitting if they are interested in the program Assessment only Control: Assessment only |
| BG002 | Total | Total of all reporting groups |
| Years |
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| Sex/Gender, Customized | Count of Participants | Participants |
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| Ethnicity (NIH/OMB) | Count of Participants | Participants |
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| Race (NIH/OMB) | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Sexual orientation | Count of Participants | Participants |
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| Income | Count of Participants | Participants |
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| Student status | Count of Participants | Participants |
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| OG001 | Assessment Only Control | After an initial enrollment message, participants will be contacted periodically to assess e-cigarette use. At the end of the intervention period, they will receive information on how to sign up for This is Quitting if they are interested in the program Assessment only Control: Assessment only |
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| Secondary | Number of Participants With Self-reported 30-day Point Prevalence Abstinence (Responder Only) | Number of participants with who responded 'No" to the question "In the past 30 days, did you vape at all, even a puff of someone else's?" Denominator is participants with responses only. | 7 month assessment responders only (Responder Only) | Posted | Count of Participants | Participants | 7 month post enrollment |
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| Secondary | Number of Participants With Self-reported 7-day Point Prevalence Abstinence (ITT) | Number of participants who responded "No" to the question "Have you used any vape, even one puff, in the past 7 days?" Denominator is all randomized participants. | All randomized participants (intent-to-treat analysis) | Posted | Count of Participants | Participants | 7 months post enrollment |
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| Secondary | Number of Participants With Self-reported 7-day Point Prevalence Abstinence (Responder Only) | Number of participants who responded "No" to the question "Have you used any vape, even one puff, in the past 7 days?" Denominator is those who responded to the question only. | Only 7-month survey responders (responder only analysis) | Posted | Count of Participants | Participants | 7 months post enrollment |
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| 0 |
| 1,304 |
| 0 |
| 1,304 |
| 0 |
| 1,304 |
| EG001 | Assessment Only Control | After an initial enrollment message, participants will be contacted periodically to assess e-cigarette use. At the end of the intervention period, they will receive information on how to sign up for This is Quitting if they are interested in the program Assessment only Control: Assessment only | 0 | 1,284 | 0 | 1,284 | 0 | 1,284 |
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