COVID shutdown

The purpose of this mechanistic study is to examine light sensitivity (melatonin suppression) in people with bipolar depression I, and compare it to healthy controls. This is not a treatment study.

The bipolar disorder I and healthy control arms are recruited from the existing Heinz C. Prechter Bipolar Research Program at the University of Michigan.

Inclusion Criteria:

• BMI 18-30 kg/m2
• Appropriate sleep schedules according to study staff. Sleep schedule is self-reported and confirmed through a sleep diary
• Healthy eyes as ascertained by eye exam at University of Michigan Kellogg Eye Center
• Willing and able to maintain stable sleep schedule during study.
• Participants will be breathalyzed and undergo urine drugs screens at every lab visit
• Acknowledge and understand that participants cannot drive themselves home after certain lab visits. Note that the research team will provide a travel stipend of $10 per visit to offset potential rideshare/taxi costs

Exclusion Criteria:

• Color blindness

There is no masking. The dim light (<1 lux) condition is first, followed by the room light (~30 lux) condition. Participants are aware of this condition order.