Background :

Diabetes is correlated to an increase in patient morbidity and mortality. The pathophysiology of diabetes is still poorly understood. Significant variations in blood sugar have been shown over time in patients with cystic fibrosis with or without diabetes. No study has evaluated the association between the nutritional profile and the glucose tolerance in adult with cystic fibrosis, by integrating data on energy consumption (detailed nutritional profile) and energy expenditure (rest energy expenditure, body composition, and physical activity).

Given the epidemiological changes in cystic fibrosis correlated to the increased prevalence of diabetes and the clinical impact of nutritional status, the association between these factors remains to be studied.

Objectives of the study :

- Main objective :

To describe adult patients with cystic fibrosis in terms of :

• Nutritional profile
• Food behaviour
• Physical activity
• Rest energy expenditure
• Body composition - Secondary objectives : To research the association between the nutritional profile and the glucose tolerance.

Study design :

The study will last 12 months. It's an observational cross-sectional study; patients are include during a scheduled review at the Cystic Fibrosis Resource and Competence Centre (CRCM de Lyon) and their participation lasts only one day. The inclusion period will last 12 months.

Expected results

The expected results are:

• Identify the inter-relationships between nutritional profile and glucose tolerance in adult patients with cystic fibrosis
• Describe the body composition and consumption on resting energy of adults with cystic fibrosis

The perspectives are:

• Propose nutritional and dietetic measures to limit the deterioration of the glucose tolerance in adult patients with cystic fibrosis
• Develop equations for evaluating consumption on resting energy specific to adult patients with cystic fibrosis in order to more specifically adapt the nutritional recommendations to each patient

The research perspectives are to compare adult patients with cystic fibrosis followed in France and Quebec in terms of:

• nutritional profiles, nutritional quality index of food and eating behaviours, resting energy expenditure, body composition
• nutritional medical practices (dietary monitoring, recommendations given to patients, intake of pancreatic enzyme).

Inclusion Criteria:

• patient (male or female) with cystic fibrosis aged 18 years and over
• pancreatic insufficiency
• followed at the CRCM adult in Lyon
• patient able to understand the information given to him
• patient having previously had a medical examination during the selection visit

Exclusion Criteria:

• FEV < 30%
• lung transplant
• patient treated with insulin
• parenteral feeding on nasogastric tube or gastrostomy
• patient under guardianship or protected by law
• patient deprived of his liberty by judicial or administrative decision
• patient currently in an another clinical study

Patient (male or female) with cystic fibrosis or pancreatic insufficiency aged 18 years and over will answer a questionnaire to identify them in terms of:

• Nutritional profile
• Eating behaviour
• Physical activity
• Resting energy expenditure
• Body composition