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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2014-01312 | Registry Identifier | CTRP |
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This double-blind, randomized crossover trial assessed inflammation and fatigue following a fast-food-type meal (saturated fat) compared to a healthier meal (monounsaturated fat) in breast cancer survivors and benign controls (women who had an initial abnormal test for breast cancer).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1 (Saturated Fat Meal, Oleic Sunflower Oil Meal) | Experimental |
| |
| Arm 2 (Oleic Sunflower Oil Meal, Saturated Fat Meal) | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Saturated Fat Meal | Other |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Post-Meal Change in C-reactive Protein | Serum CRP was obtained from blood drawn before the meal as well as 2, 4, and 7 hours post-meal. It was measured with the Vascular Injury Panel 2 Multispot Kit on an MSD Imager 2400 (both Meso Scale Discovery, Rockville, MD, USA), following kit instructions. | Blood samples were obtained before the meal (baseline) as well as 2, 4, and 7 hours post-meal |
| Post-Meal Change in Serum Amyloid A | Serum Amyloid A was obtained from blood drawn before the meal as well as 2, 4, and 7 hours post-meal. It as measured with the Vascular Injury Panel 2 Multispot Kit on an MSD Imager 2400 (both Meso Scale Discovery, Rockville, MD, USA), following kit instructions. | Blood samples were obtained before the meal (baseline) as well as 2, 4, and 7 hours post-meal |
| Change in Intercellular adhesion molecule-1 | sICAM-1 was obtained from blood drawn before the meal as well as 2, 4, and 7 hours post-meal. It was measured with the Vascular Injury Panel 2 Multispot Kit on an MSD Imager 2400 (both Meso Scale Discovery, Rockville, MD, USA), following kit instructions. | Blood samples were obtained before the meal (baseline) as well as 2, 4, and 7 hours post-meal |
| Change in Vascular cell adhesion molecule-1 | sVCAM-1 was obtained from blood drawn before the meal as well as 2, 4, and 7 hours post-meal. It was measured with the Vascular Injury Panel 2 Multispot Kit on an MSD Imager 2400 (both Meso Scale Discovery, Rockville, MD, USA), following kit instructions. | Blood samples were obtained before the meal (baseline) as well as 2, 4, and 7 hours post-meal |
| Fatigue at Follow-Up Visits | The 30-item Multidimensional Fatigue Symptom Inventory-Short form assesses behavioral, cognitive, physical, and affective expressions of fatigue. It provides a very good measure of the multidimensional aspects of fatigue, allows for comparisons between fatigued and non-fatigued individuals, and has subscales measuring general, physical, emotional, mental, and vigor aspects of fatigue, as well as a total score. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Janice Kiecolt-Glaser | Ohio State Comprehensive Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32393980 | Derived | Madison AA, Belury MA, Andridge R, Shrout MR, Renna ME, Malarkey WB, Bailey MT, Kiecolt-Glaser JK. Afternoon distraction: a high-saturated-fat meal and endotoxemia impact postmeal attention in a randomized crossover trial. Am J Clin Nutr. 2020 Jun 1;111(6):1150-1158. doi: 10.1093/ajcn/nqaa085. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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Randomized crossover trial: participants were randomized to sequence of meal type; they ate one high saturated fat meal and one high oleic sunflower oil meal with 1-4 weeks washout in between meals
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Double-blind: The data manager assigned arbitrary names to each meal so that only the data manager and the kitchen staff were unblinded.
| Oleic Sunflower Oil Meal |
| Other |
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| The survey was administered upon admission to the Clinical Research Center before the meal at both visits and at 18- and 30-month follow-up visits. |
| D017437 |
| Skin and Connective Tissue Diseases |