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Inhibitory control is relevant to many clinical disorders, including substance abuse/dependence, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. This proposal is designed to assess brain networks related to response inhibition in healthy young adults, and use neuromodulation to change these networks and behavioral performance on a response inhibition task. Having an understanding of the brain mechanisms involved in response inhibition may enable us to improve pre-existing treatments for disorders with inhibitory control difficulties.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cautious Participants | No Intervention | Participants who have low scores on a self-report of inhibitory control abilities (BRIEF-Inhibit). | |
| Impulsive Participants- Active Stimulation | Experimental | Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to active stimulation. |
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| Impulsive Participants- Sham Stimulation | Sham Comparator | Participants who have high scores on a self-report of inhibitory control abilities (BRIEF-Inhibit) who are randomized to sham stimulation. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial direct current stimulation | Device | 20 minutes of 2 milliamp transcranial direct current stimulation |
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| Measure | Description | Time Frame |
|---|---|---|
| fMRI connectivity at rest | Changes in resting state connectivity of the inhibitory control information | 2 weeks |
| fMRI connectivity during a stop signal task | Changes in task-based connectivity on the stop signal task | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Butler Hospital | Providence | Rhode Island | 02906 | United States |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |