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| Name | Class |
|---|---|
| Brain & Behavior Research Foundation | OTHER |
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Binge Eating Disorder (BED) is the most common eating disorder, and currently, the best behavioral treatments only work for 40-60% of adults. BED often co-occurs with mood and anxiety disorders, and both are associated with neurocognitive deficits related to executive function (EF). These EF deficits contribute to worsening BED symptoms and make it difficult for these adults to adhere to treatment recommendations. The proposed study aims to develop an EF training enhanced behavioral treatment for BED and compare its effectiveness to the standard cognitive behavioral therapy for patients with BED and a co-occurring mood or anxiety disorder.
A randomized controlled trial (RCT) will evaluate an EF training enhanced cognitive behavioral therapy (CBT) for BED (EF-BED+CBT) compared to standard CBT in patients with BED and a comorbid mood/anxiety disorder to assess the feasibility, acceptability, and preliminary efficacy of EF-BED+CBT in reducing binge eating, impairment, and comorbid depression/anxiety symptoms. Adult participants with BED and comorbid mood/anxiety disorder will be randomized to a four month remote treatment of either EF-BED+CBT or CBT alone. Participants will be assessed at baseline, following treatment (month 4) and 2-month follow-up (month 6).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Executive Function- Enhanced CBT for BED (EF-BED+CBT) | Experimental | EF-BED+CBT will combine CBT with executive function training, enhancing CBT with a focus on teaching compensatory strategies, habit learning, and plan for generalization to real-world behaviors. |
|
| Cognitive Behavioral Therapy (CBT) | Active Comparator | CBT will be based on the "Overcoming Binge Eating" book. CBT addresses disturbed eating patterns and problematic thoughts/beliefs related to eating, shape and weight that contribute to binge eating. CBT is the current gold standard treatment for BED. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Executive Function- Enhanced CBT for BED (EF-BED+CBT) | Behavioral | EF-BED+CBT will combine CBT (see description below) with executive function training. EF-BED will focus on teaching compensatory strategies to enhance adherence to the strategies recommended in CBT. |
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility as measured by number of treatment sessions attended | Attendance at Treatment Sessions | Over the course of 4 months of treatment |
| Acceptability | Ratings of usefulness of treatment measured by responses to Likert-type ratings developed by the study team. | At 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Binge Eating | Change in binge eating episodes measured by the Eating Disorder Examination interview | Through study completion, an average of 6 months |
| Impairment | Change in impairment measured by the Clinical Impairment Assessment (CIA). The CIA is a 16-item questionnaire with possible scores ranging from 0-48 with a higher score indicating a greater level of impairment. |
| Measure | Description | Time Frame |
|---|---|---|
| Anxiety Symptoms | Change in anxiety symptoms measured by the General Anxiety Disorder-7 (GAD-7). The GAD-7 is a 7-item questionnaire with scores ranging from 0-21 and a higher score indicating greater anxiety severity. | Through study completion, an average of 6 months |
| Depression Symptoms |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dawn M Eichen, PhD | UC San Diego | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ucsd Chear | San Diego | California | 92037 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37660487 | Derived | Eichen DM, Strong DR, Twamley EW, Boutelle KN. Adding executive function training to cognitive behavioral therapy for binge eating disorder: A pilot randomized controlled trial. Eat Behav. 2023 Dec;51:101806. doi: 10.1016/j.eatbeh.2023.101806. Epub 2023 Aug 29. |
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| ID | Term |
|---|---|
| D056912 | Binge-Eating Disorder |
| D002032 | Bulimia |
| D001008 | Anxiety Disorders |
| D019964 | Mood Disorders |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
| D006963 | Hyperphagia |
| D012817 | Signs and Symptoms, Digestive |
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| ID | Term |
|---|---|
| D001513 | Beds |
| D015928 | Cognitive Behavioral Therapy |
| ID | Term |
|---|---|
| D004865 | Equipment and Supplies, Hospital |
| D004864 | Equipment and Supplies |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
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| Cognitive Behavioral Therapy (CBT) | Behavioral | CBT will be based on the "Overcoming Binge Eating" book. All participants will be provided a copy of the book. CBT addresses disturbed eating patterns and problematic thoughts/beliefs related to eating, shape and weight that contribute to binge eating. CBT is the current gold standard treatment for BED. |
|
| Through study completion, an average of 6 months |
Change in depression symptoms measured by the Patient Health Questionnaire-9 (PHQ-9). The PHQ-9 is a 9-item questionnaire with scores ranging from 0-27 and a higher score indicating greater depression severity. |
| Through study completion, an average of 6 months |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004191 |
| Behavioral Disciplines and Activities |