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The purpose of this study is to understand how daily rhythms of behavior affect the expression of genes in fat cells, and how these daily cycles affect the way fat cells respond to insulin (a hormone that controls blood sugar levels) before and after bariatric surgery.
Bariatric surgery as a means of weight loss has become increasingly popular over the last 10-15 years. In addition to promoting weight loss, bariatric surgery has become increasingly recognized for use in the management of diabetes. Recent studies have indicated that bariatric surgery can result in a marked improvement in insulin sensitivity before long term weight loss is attained. The goal of this project is to delineate the changes in the insulin responsiveness of subcutaneous adipocytes obtained by needle biopsy 2 weeks prior to surgery vs. 12 weeks after bariatric surgery, which could account for improvements in overall insulin sensitivity seen before any long-term sustained weight loss has occurred. The investigators will also examine gene expression in adipocytes (fat cells).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Circadian Clock Alignment - High BMI | Experimental | Subjects will come to the Sleep Lab three nights before their bariatric surgery procedure for an intervention that will align their central circadian clock. The intervention includes eating meals and snacks at fixed times and having lights off at a specific time at night and lights on at a specific time in the morning. |
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| Circadian Clock Control - High BMI | Active Comparator | Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times. |
|
| Circadian Clock Control - Low BMI | Active Comparator | Subjects will not come to the Sleep Lab and will live normally at home with no changes to their meal, sleep or wake times. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Circadian Clock Alignment | Behavioral | Use timed lights and meals to align the circadian clock |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in insulin sensitivity | Insulin sensitivity will be measured as the by the phosphorylation level of Akt in adipocytes (fat cells) at baseline and 12 weeks post bariatric surgery | 12 weeks |
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Obese Subjects
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Exclusion Criteria:
Non-Obese Subjects
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Matthew Brady, PhD | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago | Chicago | Illinois | 60637 | United States |
There is currently no IRB approval or plan to make IPD available to other researchers.
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D009765 | Obesity |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Circadian Clock Control | Behavioral | No circadian clock alignment |
|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |