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Purpose: to investigate the efficacy of early exercise in patients with moderate to severe stroke regarding functional outcome and walking ability.
Methods: Patients with medium to severe stroke (NHISS >7) were recruited 24 - 48 hours after stroke onset from two stroke units in Sweden. Both groups received usual care. The intervention group received even 20 minutes bed-cycling 5 days per week with a maximum of 15 sessions. Functional outcome was measured with modified Rankin Scale (mRS) and Barthel index and walking with the 6-minute walking test (6MWT). Measurements were performed pre- and post-intervention (3 weeks), and at 3-months follow-up.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise group | Experimental | Usual care and bedcycling. |
|
| Control group | No Intervention | Usual care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Other | Bedcycling |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Modified Rankin Scale (mRS) | Functional Outcome | Baseline 24-48 hours after onset, postintervention 3 weeks after baseline and follow up 3-months after baseline. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Barthel ADL-Index | ADL | Baseline 24-48 hours after stroke onset, postintervention 3-weeks after baseline and follow up 3-months after baseline. |
| Change in 6-Minutes Walking test (6MWT) |
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Inclusion criteria:
Exclusion criteria:
• Medical or neurological diseases that can affect the performance of the exercise and severe cognitive impairment.
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| Name | Affiliation | Role |
|---|---|---|
| Paul Enthoven, PhD | Linkopings University,Sweden | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33704913 | Derived | Sandberg K, Kleist M, Enthoven P, Wijkman M. Hemodynamic responses to In-Bed Cycle Exercise in the acute phase after moderate to severe stroke: A randomized controlled trial. J Clin Hypertens (Greenwich). 2021 May;23(5):1077-1084. doi: 10.1111/jch.14232. Epub 2021 Mar 11. |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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RCT
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Walking Ability
| Baseline 24-48 hours after stroke onset, postintervention 3-weeks after baseline and follow up 3-months after baseline. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001519 | Behavior |