Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers | NCT04239573 | Trialant

Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers | NCT04239573 | Trialant

Official Title: Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers
Brief Summary: The purpose of this study is to compare two approaches for monitoring pancreatic cysts as well as to identify associated biomarkers. The study doctors want to compare more frequent monitoring versus less frequent monitoring as well as identify biomarkers which may improve risk detection of transformation to pancreatic cancer. The study doctors want to learn which monitoring method and which biomarkers lead to better outcomes for patients.
Detailed Description: PRIMARY OBJECTIVE:

I. Evaluate whether the protocol specified primary biomarkers (both blood and imaging-based) measured at baseline, are associated with the future development of worrisome features and/or high-risk stigmata.

SECONDARY OBJECTIVES:

I. Evaluate whether the imaging-based secondary biomarker implemented using baseline computed tomography (CT) scans and/or the blood-based secondary biomarker panel, is associated with the future development of worrisome features and/or high-risk stigmata.

II. Estimate area under curve (AUC), sensitivity, specificity, negative, and positive predictive value of each biomarker.

III. Evaluate the predictive ability of the longitudinal trajectory of each biomarker for prediction of worrisome features and/or high-risk stigmata.

IV. Develop and evaluate risk scores that combine blood-based and imaging-based markers.

V. Compare patient reported outcomes (PROs) between study arms (A and B): quality of life (QOL), financial distress, and situational anxiety.

VI. Compare 5-year total cost between arms (A and B).

PRIMARY OBJECTIVE (PRIOR TO ADDENDUM #5 08/13/2024):

I. To compare the rates of unfavorable clinical outcomes in the two arms.

SECONDARY OBJECTIVES (PRIOR TO ADDENDUM #5 08/13/2024):

I. To compare rates of major surgical morbidity and/or mortality between arms. II. To compare pancreatic cancer incidence and all-cause mortality across arms. III. Compare institutional (direct) costs. IV. Compare healthcare utilization of imaging, invasive testing, surgical, and other procedures across the two surveillance arms.

V. Compare patient (out-of-pocket and other indirect) costs. VI. Describe diagnostic test and treatment pathways by arm. VII. Compare patient reports of QOL, situational anxiety. VIII. Compare patient report of financial distress. IX. Compare rates of non-adherence by arm assignment. X. To evaluate and compare the predictive performance of known and future biomarkers for dysplasia or cancer.

EXPLORATORY OBJECTIVE (PRIOR TO ADDENDUM #5 08/13/2024):

I. To evaluate and compare the predictive accuracy of known and future radiomic markers for dysplasia and pancreatic cancer.

OUTLINE: This is an observational study.

Patients undergo magnetic resonance imaging (MRI) or CT scans as well as blood sample collection throughout the trial. Patients undergo endoscopic ultrasound (EUS), fine needle aspiration (FNA), biopsy and surgery as clinically indicated.

Patients are followed up every 6 months or yearly for 5 years from the date of registration.

OUTLINE (PRIOR TO ADDENDUM #5 08/13/2024): This is an observational study. Patients are randomized to 1 of 2 arms.

ARM A (LOW INTENSITY SURVEILLANCE) (CLOSED TO ACCRUAL 08/13/2024): Patients undergo MRI, CT, or EUS at the beginning of the trial and MRI or CT again in 1 year. Following the first year, patients with no abnormalities repeat MRI or CT every 2 years. Patients with positive imaging features on MRI and CT at 1 or 2 years and with negative EUS, repeat MRI or CT in 1 year. Patients with negative imaging repeat MRI or CT in 2 years.

ARM B (HIGH INTENSITY SURVEILLANCE) (CLOSED TO ACCRUAL 08/13/2024): Patients undergo MRI, CT, or EUS at the beginning of the trial. Patients with >= 1 and < 2 cm cyst undergo MRI or CT every 6 months for 1 year, then every 12 months for 2 years, and then every 24 months thereafter. Patients with >= 2 and < 3 cm cyst undergo EUS within 6 months, and if EUS is negative, patients repeat MRI or CT in 1 year. If second EUS is negative, patients undergo alternate MRI or CT and EUS every 12 months. Patients with cyst >= 3 cm undergo alternate MRI or CT with EUS every 3-6 months.

All patients may also optionally undergo blood sample collection, biopsy and/or EUS-FNA on study.

After completion of imaging procedures, patients are followed up for 5 years from the date of registration.

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Patient must be ≥ 50 years and ≤ 75 years of age

Patient must not have acute pancreatitis or a history of chronic pancreatitis

Patient must have received a CT, MRI, or EUS within 6 months prior to enrollment that revealed one or more ≥ 1 cm pancreatic cyst(s).

Patients of childbearing potential must not be known to be pregnant

Patient must not have a prior diagnosis of pancreatic malignancy of any type

Patient must not have a history of pancreatic resection

Patients with only pancreatic lesions without malignant risk (pancreatic pseudocyst or classic serous cystic lesion) are not eligible

Patient must not have a family history of pancreatic adenocarcinoma in one or more first-degree relatives (biological parents, full siblings or children)

Patient must not have pancreatic cyst morphology that would prompt immediate surgical consideration (enhancing mural nodule, solid component in cyst, pancreatic duct ≥ 10mm, cyst causing obstructive jaundice)

Patient must not have a comorbid illness that precludes EUS or pancreatic cyst resection

Patient must not be in any form of pancreatic cyst surveillance for > 1 year, defined as organized, periodic up-to-date imaging directed towards the pancreatic cyst of interest

PRIOR TO ADDENDUM #5 08/13/2024: Patient must be ≥ 50 years and ≤ 75 years of age

PRIOR TO ADDENDUM #5 08/13/2024: Patient must not have acute pancreatitis or a history of chronic pancreatitis.

PRIOR TO ADDENDUM #5 08/13/2024: Patient must have received a CT, MRI, or EUS within 6 months prior to randomization that revealed one or more ≥ 1 cm pancreatic cyst (s).

PRIOR TO ADDENDUM #5 08/13/2024: Patients of childbearing potential must not be known to be pregnant.

PRIOR TO ADDENDUM #5 08/13/2024: Patient must not have a prior diagnosis of pancreatic malignancy of any type.

PRIOR TO ADDENDUM #5 08/13/2024: Patient must not have a history of pancreatic resection.

PRIOR TO ADDENDUM #5 08/13/2024: Patients with only pancreatic lesions without malignant risk (pancreatic pseudocyst or classic serous cystic lesion) are not eligible.

PRIOR TO ADDENDUM #5 08/13/2024: Patient must not have a family history of pancreatic adenocarcinoma in one or more first-degree relatives (biological parents, full siblings or children).

PRIOR TO ADDENDUM #5 08/13/2024: Patient must not have pancreatic cyst morphology that would prompt immediate surgical consideration (enhancing mural nodule, solid component in cyst, pancreatic duct ≥10mm, cyst causing obstructive jaundice).

PRIOR TO ADDENDUM #5 08/13/2024: Patient must not have a comorbid illness that precludes EUS or pancreatic cyst resection.

University of Alabama at Birmingham Cancer CenterRecruiting

Birmingham, Alabama 35233, United States

Site Public ContactContact

gingerreeves@uabmc.edu

Samuel GalganoPrincipal Investigator

University of South Alabama Mitchell Cancer InstituteRecruiting

Mobile, Alabama 36688, United States

Anchorage Associates in Radiation MedicineRecruiting

Anchorage, Alaska 98508, United States

Anchorage Radiation Therapy CenterSuspended

Anchorage, Alaska 99504, United States

Alaska Breast Care and Surgery LLCRecruiting

Anchorage, Alaska 99508, United States

Alaska Oncology and Hematology LLCRecruiting

Anchorage, Alaska 99508, United States

Alaska Women's Cancer CareRecruiting

Anchorage, Alaska 99508, United States

Anchorage Oncology CentreSuspended

Anchorage, Alaska 99508, United States

Katmai Oncology GroupRecruiting

Anchorage, Alaska 99508, United States

Providence Alaska Medical CenterRecruiting

Anchorage, Alaska 99508, United States

Mayo Clinic Hospital in ArizonaRecruiting

Phoenix, Arizona 85054, United States

Mayo Clinic in ArizonaRecruiting

Scottsdale, Arizona 85259, United States

Baptist Health Medical Center - Little RockSuspended

Little Rock, Arkansas 72205, United States

University of Arkansas for Medical SciencesRecruiting

Little Rock, Arkansas 72205, United States

Providence Saint Joseph Medical Center/Disney Family Cancer CenterRecruiting

Burbank, California 91505, United States

UC San Diego Health System - EncinitasSuspended

Encinitas, California 92024, United States

UC San Diego Moores Cancer CenterRecruiting

La Jolla, California 92093, United States

Loma Linda University Medical CenterRecruiting

Loma Linda, California 92354, United States

Veterans Affairs Loma Linda Healthcare SystemActive, not recruiting

Loma Linda, California 92357, United States

UCLA / Jonsson Comprehensive Cancer CenterRecruiting

Los Angeles, California 90095, United States

University of California Davis Comprehensive Cancer CenterRecruiting

Sacramento, California 95817, United States

UC San Diego Medical Center - HillcrestSuspended

San Diego, California 92103, United States

UCSF Medical Center-Mount ZionRecruiting

San Francisco, California 94115, United States

UCSF Medical Center-ParnassusRecruiting

San Francisco, California 94143, United States

UCSF Medical Center-Mission BayRecruiting

San Francisco, California 94158, United States

Smilow Cancer Hospital-Derby Care CenterRecruiting

Derby, Connecticut 06418, United States

Smilow Cancer Hospital Care Center-FairfieldRecruiting

Fairfield, Connecticut 06824, United States

Smilow Cancer Hospital Care Center at GlastonburyRecruiting

Glastonbury, Connecticut 06033, United States

Smilow Cancer Hospital Care Center at GreenwichRecruiting

Greenwich, Connecticut 06830, United States

Smilow Cancer Hospital Care Center - GuilfordRecruiting

Guilford, Connecticut 06437, United States

Smilow Cancer Hospital-Hamden Care CenterRecruiting

Hamden, Connecticut 06518, United States

Smilow Cancer Hospital Care Center at Saint FrancisRecruiting

Hartford, Connecticut 06105, United States

Smilow Cancer Center/Yale-New Haven HospitalRecruiting

New Haven, Connecticut 06510, United States

Yale-New Haven Hospital Saint Raphael CampusRecruiting

New Haven, Connecticut 06511, United States

Yale UniversityRecruiting

New Haven, Connecticut 06520, United States

Yale-New Haven Hospital North Haven Medical CenterRecruiting

North Haven, Connecticut 06473, United States

Smilow Cancer Hospital-Orange Care CenterRecruiting

Orange, Connecticut 06477, United States

Smilow Cancer Hospital-Torrington Care CenterRecruiting

Torrington, Connecticut 06790, United States

Smilow Cancer Hospital Care Center-TrumbullRecruiting

Trumbull, Connecticut 06611, United States

Smilow Cancer Hospital-Waterbury Care CenterRecruiting

Waterbury, Connecticut 06708, United States

Smilow Cancer Hospital Care Center - WaterfordRecruiting

Waterford, Connecticut 06385, United States

Veterans Affairs Connecticut Healthcare System-West Haven CampusRecruiting

West Haven, Connecticut 06516, United States

Beebe Medical CenterRecruiting

Lewes, Delaware 19958, United States

Beebe South Coastal Health CampusRecruiting

Millville, Delaware 19967, United States

Helen F Graham Cancer CenterRecruiting

Newark, Delaware 19713, United States

Medical Oncology Hematology Consultants PARecruiting

Newark, Delaware 19713, United States

Christiana Care Health System-Christiana HospitalRecruiting

Newark, Delaware 19718, United States

Beebe Health CampusRecruiting

Rehoboth Beach, Delaware 19971, United States

Christiana Care Health System-Wilmington HospitalRecruiting

Wilmington, Delaware 19801, United States

MedStar Georgetown University HospitalRecruiting

Washington D.C., District of Columbia 20007, United States

Holy Cross HospitalRecruiting

Fort Lauderdale, Florida 33308, United States

Regional Cancer Center-Lee Memorial Health SystemRecruiting

Fort Myers, Florida 33905, United States

Mayo Clinic in FloridaRecruiting

Jacksonville, Florida 32224-9980, United States

Lakeland Regional Health Hollis Cancer CenterRecruiting

Lakeland, Florida 33805, United States

Emory University Hospital MidtownRecruiting

Atlanta, Georgia 30308, United States

Emory University Hospital/Winship Cancer InstituteRecruiting

Atlanta, Georgia 30322, United States

Emory Saint Joseph's HospitalRecruiting

Atlanta, Georgia 30342, United States

Saint Alphonsus Cancer Care Center-BoiseRecruiting

Boise, Idaho 83706, United States

Saint Luke's Cancer Institute - BoiseRecruiting

Boise, Idaho 83712, United States

Saint Alphonsus Cancer Care Center-CaldwellRecruiting

Caldwell, Idaho 83605, United States

Saint Luke's Cancer Institute - FruitlandRecruiting

Fruitland, Idaho 83619, United States

Idaho Urologic Institute-MeridianRecruiting

Meridian, Idaho 83642, United States

Saint Luke's Cancer Institute - MeridianRecruiting

Meridian, Idaho 83642, United States

Saint Alphonsus Cancer Care Center-NampaRecruiting

Nampa, Idaho 83687, United States

Saint Luke's Cancer Institute - NampaRecruiting

Nampa, Idaho 83687, United States

Saint Luke's Cancer Institute - Twin FallsRecruiting

Twin Falls, Idaho 83301, United States

Advocate Outpatient Center - AuroraRecruiting

Aurora, Illinois 60506, United States

Advocate Good Shepherd HospitalRecruiting

Barrington, Illinois 60010, United States

Carle BroMenn Outpatient CenterRecruiting

Bloomington, Illinois 61704, United States

Illinois CancerCare-BloomingtonRecruiting

Bloomington, Illinois 61704, United States

Illinois CancerCare-CantonRecruiting

Canton, Illinois 61520, United States

Memorial Hospital of CarbondaleRecruiting

Carbondale, Illinois 62902, United States

SIH Cancer InstituteRecruiting

Carterville, Illinois 62918, United States

Illinois CancerCare-CarthageRecruiting

Carthage, Illinois 62321, United States

Centralia Oncology ClinicRecruiting

Centralia, Illinois 62801, United States

Northwestern UniversityRecruiting

Chicago, Illinois 60611, United States

Advocate Illinois Masonic Medical CenterRecruiting

Chicago, Illinois 60657, United States

AMG Crystal Lake - OncologyRecruiting

Crystal Lake, Illinois 60014, United States

Carle at The RiverfrontRecruiting

Danville, Illinois 61832, United States

Cancer Care Specialists of Illinois - DecaturRecruiting

Decatur, Illinois 62526, United States

Decatur Memorial HospitalRecruiting

Decatur, Illinois 62526, United States

Northwestern Medicine Cancer Center KishwaukeeRecruiting

DeKalb, Illinois 60115, United States

Illinois CancerCare-DixonRecruiting

Dixon, Illinois 61021, United States

Advocate Good Samaritan HospitalRecruiting

Downers Grove, Illinois 60515, United States

Carle Physician Group-EffinghamRecruiting

Effingham, Illinois 62401, United States

Crossroads Cancer CenterRecruiting

Effingham, Illinois 62401, United States

Advocate Sherman HospitalRecruiting

Elgin, Illinois 60123, United States

Elmhurst Memorial HospitalRecruiting

Elmhurst, Illinois 60126, United States

Illinois CancerCare-EurekaRecruiting

Eureka, Illinois 61530, United States

NorthShore University HealthSystem-Evanston HospitalActive, not recruiting

Evanston, Illinois 60201, United States

Illinois CancerCare-GalesburgRecruiting

Galesburg, Illinois 61401, United States

Western Illinois Cancer Treatment CenterSuspended

Galesburg, Illinois 61401, United States

Northwestern Medicine Cancer Center DelnorRecruiting

Geneva, Illinois 60134, United States

NorthShore University HealthSystem-Glenbrook HospitalActive, not recruiting

Glenview, Illinois 60026, United States

Ingalls Memorial HospitalActive, not recruiting

Harvey, Illinois 60426, United States

Advocate South Suburban HospitalRecruiting

Hazel Crest, Illinois 60429, United States

NorthShore University HealthSystem-Highland Park HospitalActive, not recruiting

Highland Park, Illinois 60035, United States

Illinois CancerCare-Kewanee ClinicRecruiting

Kewanee, Illinois 61443, United States

Northwestern Medicine Lake Forest HospitalActive, not recruiting

Lake Forest, Illinois 60045, United States

AMG Libertyville - OncologyRecruiting

Libertyville, Illinois 60048, United States

Condell Memorial HospitalRecruiting

Libertyville, Illinois 60048, United States

Illinois CancerCare-MacombRecruiting

Macomb, Illinois 61455, United States

Carle Physician Group-Mattoon/CharlestonRecruiting

Mattoon, Illinois 61938, United States

Edward Hospital/Cancer CenterRecruiting

Naperville, Illinois 60540, United States

Carle BroMenn Medical CenterRecruiting

Normal, Illinois 61761, United States

Carle Cancer Institute NormalRecruiting

Normal, Illinois 61761, United States

Cancer Care Center of O'FallonRecruiting

O'Fallon, Illinois 62269, United States

HSHS Saint Elizabeth's HospitalRecruiting

O'Fallon, Illinois 62269, United States

Northwestern Medicine Oak BrookRecruiting

Oak Brook, Illinois 60523, United States

Advocate Christ Medical CenterRecruiting

Oak Lawn, Illinois 60453-2699, United States

Northwestern Medicine Orland ParkRecruiting

Orland Park, Illinois 60462, United States

Illinois CancerCare-Ottawa ClinicRecruiting

Ottawa, Illinois 61350, United States

Advocate Lutheran General HospitalRecruiting

Park Ridge, Illinois 60068, United States

Illinois CancerCare-PekinRecruiting

Pekin, Illinois 61554, United States

Illinois CancerCare-PeoriaRecruiting

Peoria, Illinois 61615, United States

Methodist Medical Center of IllinoisRecruiting

Peoria, Illinois 61636, United States

Illinois CancerCare-PeruRecruiting

Peru, Illinois 61354, United States

Valley Radiation OncologyRecruiting

Peru, Illinois 61354, United States

Edward Hospital/Cancer Center?PlainfieldRecruiting

Plainfield, Illinois 60585, United States

Illinois CancerCare-PrincetonRecruiting

Princeton, Illinois 61356, United States

Southern Illinois University School of MedicineRecruiting

Springfield, Illinois 62702, United States

Springfield ClinicRecruiting

Springfield, Illinois 62702, United States

Springfield Memorial HospitalRecruiting

Springfield, Illinois 62781, United States

Southwest Illinois Health Services LLPSuspended

Swansea, Illinois 62226, United States

Carle Cancer CenterRecruiting

Urbana, Illinois 61801, United States

The Carle Foundation HospitalRecruiting

Urbana, Illinois 61801, United States

Northwestern Medicine Cancer Center WarrenvilleRecruiting

Warrenville, Illinois 60555, United States

Illinois CancerCare - WashingtonRecruiting

Washington, Illinois 61571, United States

Indiana University/Melvin and Bren Simon Cancer CenterRecruiting

Indianapolis, Indiana 46202, United States

Reid HealthActive, not recruiting

Richmond, Indiana 47374, United States

UI Health Care Mission Cancer and Blood - Ankeny ClinicRecruiting

Ankeny, Iowa 50023, United States

Mercy Cancer Center-West LakesRecruiting

Clive, Iowa 50325, United States

UI Health Care Mission Cancer and Blood - West Des Moines ClinicRecruiting

Clive, Iowa 50325, United States

Greater Regional Medical CenterRecruiting

Creston, Iowa 50801, United States

Iowa Methodist Medical CenterRecruiting

Des Moines, Iowa 50309, United States

UI Health Care Mission Cancer and Blood - Des Moines ClinicRecruiting

Des Moines, Iowa 50309, United States

Mercy Medical Center - Des MoinesRecruiting

Des Moines, Iowa 50314, United States

UI Health Care Mission Cancer and Blood - Laurel ClinicRecruiting

Des Moines, Iowa 50314, United States

University of Iowa/Holden Comprehensive Cancer CenterRecruiting

Iowa City, Iowa 52242, United States

UI Health Care Mission Cancer and Blood - Waukee ClinicRecruiting

Waukee, Iowa 50263, United States

Mercy Medical Center-West LakesRecruiting

West Des Moines, Iowa 50266, United States

LSU Health Baton Rouge-North ClinicRecruiting

Baton Rouge, Louisiana 70805, United States

Our Lady of the Lake Physician GroupRecruiting

Baton Rouge, Louisiana 70808, United States

Our Lady of The LakeRecruiting

Baton Rouge, Louisiana 70808, United States

Mary Bird Perkins Cancer CenterActive, not recruiting

Baton Rouge, Louisiana 70809, United States

Christiana Care - Union HospitalRecruiting

Elkton, Maryland 21921, United States

UM Baltimore Washington Medical Center/Tate Cancer CenterActive, not recruiting

Glen Burnie, Maryland 21061, United States

MyMichigan Medical Center GratiotRecruiting

Alma, Michigan 48801, United States

MyMichigan Medical Center AlpenaRecruiting

Alpena, Michigan 49707, United States

Trinity Health Saint Joseph Mercy Hospital Ann ArborRecruiting

Ann Arbor, Michigan 48106, United States

University of Michigan Rogel Cancer CenterRecruiting

Ann Arbor, Michigan 48109, United States

Bronson Battle CreekRecruiting

Battle Creek, Michigan 49017, United States

Trinity Health IHA Medical Group Hematology Oncology - BrightonRecruiting

Brighton, Michigan 48114, United States

Trinity Health Medical Center - BrightonRecruiting

Brighton, Michigan 48114, United States

Trinity Health IHA Medical Group Hematology Oncology - CantonRecruiting

Canton, Michigan 48188, United States

Trinity Health Medical Center - CantonRecruiting

Canton, Michigan 48188, United States

Chelsea HospitalRecruiting

Chelsea, Michigan 48118, United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalRecruiting

Chelsea, Michigan 48118, United States

Hematology Oncology Consultants-ClarkstonRecruiting

Clarkston, Michigan 48346, United States

Newland Medical Associates-ClarkstonSuspended

Clarkston, Michigan 48346, United States

Corewell Health Dearborn HospitalRecruiting

Dearborn, Michigan 48124, United States

Henry Ford Health Saint John HospitalRecruiting

Detroit, Michigan 48236, United States

Henry Ford River District HospitalRecruiting

East China, Michigan 48054, United States

Site Public ContactContact

kforman1@hfhs.org313-343-3166

Corewell Health Farmington Hills HospitalRecruiting

Farmington Hills, Michigan 48336, United States

Cancer Hematology Centers - FlintRecruiting

Flint, Michigan 48503, United States

Genesee Hematology Oncology PCRecruiting

Flint, Michigan 48503, United States

Genesys Hurley Cancer InstituteRecruiting

Flint, Michigan 48503, United States

Hurley Medical CenterRecruiting

Flint, Michigan 48503, United States

MyMichigan Medical Center GladwinRecruiting

Gladwin, Michigan 48624, United States

Corewell Health Grand Rapids Hospitals - Butterworth HospitalRecruiting

Grand Rapids, Michigan 49503, United States

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalRecruiting

Grand Rapids, Michigan 49503, United States

Trinity Health Grand Rapids HospitalRecruiting

Grand Rapids, Michigan 49503, United States

Henry Ford Saint John Hospital - AcademicRecruiting

Grosse Pointe Woods, Michigan 48236, United States

Henry Ford Saint John Hospital - BreastRecruiting

Grosse Pointe Woods, Michigan 48236, United States

Henry Ford Saint John Hospital - Van ElslanderRecruiting

Grosse Pointe Woods, Michigan 48236, United States

Bronson Methodist HospitalRecruiting

Kalamazoo, Michigan 49007, United States

West Michigan Cancer CenterRecruiting

Kalamazoo, Michigan 49007, United States

Beacon Kalamazoo Cancer CenterRecruiting

Kalamazoo, Michigan 49009, United States

Beacon KalamazooRecruiting

Kalamazoo, Michigan 49048, United States

University of Michigan Health - Sparrow LansingRecruiting

Lansing, Michigan 48912, United States

Trinity Health Saint Mary Mercy Livonia HospitalRecruiting

Livonia, Michigan 48154, United States

Henry Ford Saint John Hospital - Macomb MedicalRecruiting

Macomb, Michigan 48044, United States

Henry Ford Warren Hospital - Breast MacombRecruiting

Macomb, Michigan 48044, United States

MyMichigan Medical Center MidlandRecruiting

Midland, Michigan 48670, United States

MyMichigan Medical Center Mount PleasantRecruiting

Mount Pleasant, Michigan 48858, United States

Trinity Health Muskegon HospitalRecruiting

Muskegon, Michigan 49444, United States

Corewell Health Lakeland Hospitals - Niles HospitalRecruiting

Niles, Michigan 49120, United States

Cancer and Hematology Centers of Western Michigan - Norton ShoresSuspended

Norton Shores, Michigan 49444, United States

Hope Cancer CenterSuspended

Pontiac, Michigan 48341, United States

Michigan Healthcare Professionals PontiacRecruiting

Pontiac, Michigan 48341, United States

Newland Medical Associates-PontiacRecruiting

Pontiac, Michigan 48341, United States

Trinity Health Saint Joseph Mercy Oakland HospitalRecruiting

Pontiac, Michigan 48341, United States

Corewell Health Reed City HospitalRecruiting

Reed City, Michigan 49677, United States

Oakland Colon Rectal AssociatesRecruiting

Royal Oak, Michigan 48067, United States

Cancer Care Associates PCRecruiting

Royal Oak, Michigan 48073, United States

Comprehensive Medical Center PLLCRecruiting

Royal Oak, Michigan 48073, United States

Corewell Health William Beaumont University HospitalRecruiting

Royal Oak, Michigan 48073, United States

Hematology Oncology Consultants PC-Royal OakRecruiting

Royal Oak, Michigan 48073, United States

Oakland Medical GroupRecruiting

Royal Oak, Michigan 48073, United States

MyMichigan Medical Center SaginawRecruiting

Saginaw, Michigan 48601, United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterRecruiting

Saint Joseph, Michigan 49085, United States

Corewell Health Lakeland Hospitals - Saint Joseph HospitalRecruiting

Saint Joseph, Michigan 49085, United States

Premier Hematology Oncology CareRecruiting

Sterling Heights, Michigan 48312, United States

MyMichigan Medical Center TawasRecruiting

Tawas City, Michigan 48764, United States

Munson Medical CenterRecruiting

Traverse City, Michigan 49684, United States

Michigan Institute of Urology-Town CenterRecruiting

Troy, Michigan 48084, United States

Corewell Health Beaumont Troy HospitalRecruiting

Troy, Michigan 48085, United States

Hematology Oncology Consultants PC-TroyRecruiting

Troy, Michigan 48098, United States

Henry Ford Health Warren HospitalRecruiting

Warren, Michigan 48093, United States

Henry Ford Madison Heights Hospital - BreastRecruiting

Warren, Michigan 48093, United States

Henry Ford Warren Hospital - GLCMSRecruiting

Warren, Michigan 48093, United States

University of Michigan Health - WestRecruiting

Wyoming, Michigan 49519, United States

Huron Gastroenterology PCRecruiting

Ypsilanti, Michigan 48106, United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusRecruiting

Ypsilanti, Michigan 48197, United States

Sanford Joe Lueken Cancer CenterRecruiting

Bemidji, Minnesota 56601, United States

Mayo Clinic in RochesterRecruiting

Rochester, Minnesota 55905, United States

Sanford Thief River Falls Medical CenterRecruiting

Thief River Falls, Minnesota 56701, United States

Sanford Cancer Center WorthingtonRecruiting

Worthington, Minnesota 56187, United States

Mercy Cancer Center - Cape GirardeauSuspended

Cape Girardeau, Missouri 63703, United States

Saint Francis Medical CenterRecruiting

Cape Girardeau, Missouri 63703, United States

Parkland Health Center - FarmingtonRecruiting

Farmington, Missouri 63640, United States

MU Health Care Goldschmidt Cancer CenterSuspended

Jefferson City, Missouri 65109, United States

Sainte Genevieve County Memorial HospitalRecruiting

Sainte Genevieve, Missouri 63670, United States

Washington University School of MedicineRecruiting

St Louis, Missouri 63110, United States

Missouri Baptist Medical CenterRecruiting

St Louis, Missouri 63131, United States

Missouri Baptist Sullivan HospitalRecruiting

Sullivan, Missouri 63080, United States

Saint Patrick Hospital - Community HospitalRecruiting

Missoula, Montana 59802, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterActive, not recruiting

Lebanon, New Hampshire 03756, United States

Veterans Adminstration New Jersey Health Care SystemActive, not recruiting

East Orange, New Jersey 07018-1095, United States

Englewood Hospital and Medical CenterRecruiting

Englewood, New Jersey 07631, United States

CentraState Medical CenterRecruiting

Freehold, New Jersey 07728, United States

Morristown Medical CenterRecruiting

Morristown, New Jersey 07960, United States

Saint Peter's University HospitalRecruiting

New Brunswick, New Jersey 08901, United States

Capital Health Medical Center-HopewellActive, not recruiting

Pennington, New Jersey 08534, United States

Penn Medicine Princeton HealthSuspended

Plainsboro, New Jersey 08536, United States

Overlook HospitalRecruiting

Summit, New Jersey 07902, United States

University of New Mexico Cancer CenterRecruiting

Albuquerque, New Mexico 87106, United States

Roswell Park Cancer InstituteRecruiting

Buffalo, New York 14263, United States

Glens Falls HospitalRecruiting

Glens Falls, New York 12801, United States

Northwell Health/Center for Advanced MedicineRecruiting

Lake Success, New York 11042, United States

Laura and Isaac Perlmutter Cancer Center at NYU LangoneSuspended

New York, New York 10016, United States

Manhattan Eye Ear and Throat HospitalRecruiting

New York, New York 10065, United States

Lenox Hill HospitalRecruiting

New York, New York 10075, United States

Stony Brook University Medical CenterRecruiting

Stony Brook, New York 11794, United States

Montefiore Medical Center-Einstein CampusRecruiting

The Bronx, New York 10461, United States

Montefiore Medical Center-Weiler HospitalRecruiting

The Bronx, New York 10461, United States

Montefiore Medical Center - Moses CampusRecruiting

The Bronx, New York 10467, United States

UNC Lineberger Comprehensive Cancer CenterRecruiting

Chapel Hill, North Carolina 27599, United States

Durham VA Medical CenterRecruiting

Durham, North Carolina 27705, United States

East Carolina UniversityRecruiting

Greenville, North Carolina 27834, United States

University of North Carolina-Hillsborough CampusRecruiting

Hillsborough, North Carolina 27278, United States

Wake Forest University Health SciencesActive, not recruiting

Winston-Salem, North Carolina 27157, United States

Sanford Bismarck Medical CenterRecruiting

Bismarck, North Dakota 58501, United States

Sanford South University Medical CenterRecruiting

Fargo, North Dakota 58103, United States

Southpointe-Sanford Medical Center FargoRecruiting

Fargo, North Dakota 58103, United States

Sanford Medical Center FargoRecruiting

Fargo, North Dakota 58104, United States

Sanford Broadway Medical CenterRecruiting

Fargo, North Dakota 58122, United States

Sanford Roger Maris Cancer CenterRecruiting

Fargo, North Dakota 58122, United States

Indu and Raj Soin Medical CenterActive, not recruiting

Beavercreek, Ohio 45431, United States

Saint Elizabeth Boardman HospitalActive, not recruiting

Boardman, Ohio 44512, United States

Dayton Physicians LLC-Miami Valley SouthActive, not recruiting

Centerville, Ohio 45459, United States

Miami Valley Hospital SouthSuspended

Centerville, Ohio 45459, United States

Oncology Hematology Care Inc-KenwoodActive, not recruiting

Cincinnati, Ohio 45236, United States

MetroHealth Medical CenterActive, not recruiting

Cleveland, Ohio 44109, United States

Ohio State University Comprehensive Cancer CenterRecruiting

Columbus, Ohio 43210, United States

Miami Valley HospitalSuspended

Dayton, Ohio 45409, United States

Dayton Physician LLC - EnglewoodActive, not recruiting

Dayton, Ohio 45415, United States

Miami Valley Hospital NorthSuspended

Dayton, Ohio 45415, United States

Armes Family Cancer CenterActive, not recruiting

Findlay, Ohio 45840, United States

Blanchard Valley HospitalActive, not recruiting

Findlay, Ohio 45840, United States

Orion Cancer CareActive, not recruiting

Findlay, Ohio 45840, United States

Atrium Medical Center-Middletown Regional HospitalSuspended

Franklin, Ohio 45005-1066, United States

Dayton Physicians LLC-AtriumActive, not recruiting

Franklin, Ohio 45005, United States

Dayton Physicians LLC-WayneActive, not recruiting

Greenville, Ohio 45331, United States

Wayne HospitalActive, not recruiting

Greenville, Ohio 45331, United States

Greater Dayton Cancer CenterActive, not recruiting

Kettering, Ohio 45409, United States

Kettering Medical CenterActive, not recruiting

Kettering, Ohio 45429, United States

Springfield Regional Cancer CenterSuspended

Springfield, Ohio 45504, United States

Springfield Regional Medical CenterSuspended

Springfield, Ohio 45504, United States

Dayton Physicians LLC - TroyActive, not recruiting

Troy, Ohio 45373, United States

Upper Valley Medical CenterSuspended

Troy, Ohio 45373, United States

Saint Joseph Warren HospitalActive, not recruiting

Warren, Ohio 44484, United States

Saint Elizabeth Youngstown HospitalActive, not recruiting

Youngstown, Ohio 44501, United States

University of Oklahoma Health Sciences CenterRecruiting

Oklahoma City, Oklahoma 73104, United States

Saint Alphonsus Cancer Care Center-Baker CityRecruiting

Baker City, Oregon 97814, United States

Saint Charles Health SystemRecruiting

Bend, Oregon 97701, United States

Clackamas Radiation Oncology CenterRecruiting

Clackamas, Oregon 97015, United States

Providence Cancer Institute Clackamas ClinicSuspended

Clackamas, Oregon 97015, United States

Bay Area HospitalRecruiting

Coos Bay, Oregon 97420, United States

Providence Hood River Memorial HospitalRecruiting

Hood River, Oregon 97031, United States

Providence Newberg Medical CenterRecruiting

Newberg, Oregon 97132, United States

Saint Alphonsus Cancer Care Center-OntarioRecruiting

Ontario, Oregon 97914, United States

Providence Willamette Falls Medical CenterRecruiting

Oregon City, Oregon 97045, United States

Providence Portland Medical CenterRecruiting

Portland, Oregon 97213, United States

Providence Saint Vincent Medical CenterRecruiting

Portland, Oregon 97225, United States

Oregon Health and Science UniversityRecruiting

Portland, Oregon 97239, United States

Saint Charles Health System-RedmondRecruiting

Redmond, Oregon 97756, United States

Lehigh Valley Hospital-Cedar CrestRecruiting

Allentown, Pennsylvania 18103, United States

Saint Luke's Cancer Center - AllentownRecruiting

Allentown, Pennsylvania 18104, United States

Saint Luke's University Hospital-Bethlehem CampusRecruiting

Bethlehem, Pennsylvania 18015, United States

Lehigh Valley Hospital - MuhlenbergRecruiting

Bethlehem, Pennsylvania 18017, United States

Bryn Mawr HospitalRecruiting

Bryn Mawr, Pennsylvania 19010, United States

Christiana Care Health System-Concord Health CenterRecruiting

Chadds Ford, Pennsylvania 19317, United States

Main Line Health Center-CollegevilleSuspended

Collegeville, Pennsylvania 19426, United States

Geisinger Medical CenterRecruiting

Danville, Pennsylvania 17822, United States

Pocono Medical CenterRecruiting

East Stroudsburg, Pennsylvania 18301, United States

Saint Luke's Hospital-Anderson CampusRecruiting

Easton, Pennsylvania 18045, United States

Main Line Health Center-ExtonSuspended

Exton, Pennsylvania 19341, United States

Lehigh Valley Hospital-HazletonRecruiting

Hazleton, Pennsylvania 18201, United States

Riddle Memorial HospitalRecruiting

Media, Pennsylvania 19063, United States

Paoli Memorial HospitalRecruiting

Paoli, Pennsylvania 19301, United States

University of Pennsylvania/Abramson Cancer CenterRecruiting

Philadelphia, Pennsylvania 19104, United States

Thomas Jefferson University HospitalRecruiting

Philadelphia, Pennsylvania 19107, United States

Fox Chase Cancer CenterRecruiting

Philadelphia, Pennsylvania 19111, United States

Saint Luke's Hospital - Upper Bucks CampusRecruiting

Quakertown, Pennsylvania 18951, United States

Saint Luke's Hospital-Quakertown CampusSuspended

Quakertown, Pennsylvania 18951, United States

Saint Luke's Hospital - Monroe CampusRecruiting

Stroudsburg, Pennsylvania 18360, United States

Geisinger Wyoming Valley/Henry Cancer CenterRecruiting

Wilkes-Barre, Pennsylvania 18711, United States

Lankenau Medical CenterRecruiting

Wynnewood, Pennsylvania 19096, United States

Smilow Cancer Hospital Care Center - WesterlyRecruiting

Westerly, Rhode Island 02891, United States

Prisma Health Cancer Institute - SpartanburgActive, not recruiting

Boiling Springs, South Carolina 29316, United States

Roper HospitalRecruiting

Charleston, South Carolina 29401, United States

Bon Secours Saint Francis HospitalRecruiting

Charleston, South Carolina 29414, United States

Prisma Health Cancer Institute - LaurensActive, not recruiting

Clinton, South Carolina 29325, United States

Prisma Health Richland HospitalRecruiting

Columbia, South Carolina 29203, United States

Prisma Health Baptist HospitalSuspended

Columbia, South Carolina 29220, United States

Prisma Health Cancer Institute - EasleyActive, not recruiting

Easley, South Carolina 29640, United States

Tidelands Georgetown Memorial HospitalActive, not recruiting

Georgetown, South Carolina 29440, United States

Prisma Health Cancer Institute - ButternutActive, not recruiting

Greenville, South Carolina 29605, United States

Prisma Health Cancer Institute - FarisActive, not recruiting

Greenville, South Carolina 29605, United States

Prisma Health Greenville Memorial HospitalRecruiting

Greenville, South Carolina 29605, United States

Prisma Health Cancer Institute - EastsideActive, not recruiting

Greenville, South Carolina 29615, United States

Prisma Health Cancer Institute - GreerActive, not recruiting

Greer, South Carolina 29650, United States

Prisma Health Cancer Institute - SenecaActive, not recruiting

Seneca, South Carolina 29672, United States

Sanford Cancer Center Oncology ClinicRecruiting

Sioux Falls, South Dakota 57104, United States

Sanford USD Medical Center - Sioux FallsRecruiting

Sioux Falls, South Dakota 57117-5134, United States

University of Tennessee - KnoxvilleRecruiting

Knoxville, Tennessee 37920, United States

Baptist Memorial Hospital and Cancer Center-MemphisActive, not recruiting

Memphis, Tennessee 38120, United States

Vanderbilt University/Ingram Cancer CenterRecruiting

Nashville, Tennessee 37232, United States

UT Southwestern/Simmons Cancer Center-DallasRecruiting

Dallas, Texas 75390, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterRecruiting

Houston, Texas 77030, United States

University of Texas Health Science Center at San AntonioActive, not recruiting

San Antonio, Texas 78229, United States

Huntsman Cancer Institute/University of UtahRecruiting

Salt Lake City, Utah 84112, United States

Central Vermont Medical Center/National Life Cancer TreatmentRecruiting

Berlin Corners, Vermont 05602, United States

University of Vermont Medical CenterRecruiting

Burlington, Vermont 05401, United States

University of Vermont and State Agricultural CollegeRecruiting

Burlington, Vermont 05405, United States

Inova Alexandria HospitalRecruiting

Alexandria, Virginia 22304, United States

University of Virginia Cancer CenterRecruiting

Charlottesville, Virginia 22908, United States

Inova Schar Cancer InstituteRecruiting

Fairfax, Virginia 22031, United States

Inova Fair Oaks HospitalRecruiting

Fairfax, Virginia 22033, United States

Inova Fairfax HospitalRecruiting

Falls Church, Virginia 22042, United States

Inova Loudoun HospitalRecruiting

Leesburg, Virginia 20176, United States

Sentara Norfolk General HospitalRecruiting

Norfolk, Virginia 23507, United States

VCU Massey Cancer Center at Stony PointRecruiting

Richmond, Virginia 23235, United States

VCU Massey Comprehensive Cancer CenterRecruiting

Richmond, Virginia 23298, United States

Carilion Roanoke Memorial HospitalActive, not recruiting

Roanoke, Virginia 24033, United States

Valley Health / Winchester Medical CenterRecruiting

Winchester, Virginia 22601, United States

Providence Regional Cancer System-AberdeenRecruiting

Aberdeen, Washington 98520, United States

PeaceHealth Saint Joseph Medical CenterRecruiting

Bellingham, Washington 98225, United States

Providence Regional Cancer System-CentraliaRecruiting

Centralia, Washington 98531, United States

Swedish Cancer Institute-EdmondsRecruiting

Edmonds, Washington 98026, United States

Providence Regional Cancer PartnershipRecruiting

Everett, Washington 98201, United States

Swedish Cancer Institute-IssaquahRecruiting

Issaquah, Washington 98029, United States

Kadlec Clinic Hematology and OncologyRecruiting

Kennewick, Washington 99336, United States

Providence Regional Cancer System-LaceyRecruiting

Lacey, Washington 98503, United States

PeaceHealth Saint John Medical CenterRecruiting

Longview, Washington 98632, United States

Skagit Regional Health Cancer Care CenterRecruiting

Mount Vernon, Washington 98274, United States

Virginia Mason Medical CenterActive, not recruiting

Seattle, Washington 98101, United States

Pacific Gynecology SpecialistsSuspended

Seattle, Washington 98104, United States

Swedish Medical Center-Ballard CampusRecruiting

Seattle, Washington 98107, United States

Swedish Medical Center-Cherry HillRecruiting

Seattle, Washington 98122-5711, United States

Swedish Medical Center-First HillRecruiting

Seattle, Washington 98122, United States

PeaceHealth United General Medical CenterRecruiting

Sedro-Woolley, Washington 98284, United States

Providence Regional Cancer System-SheltonSuspended

Shelton, Washington 98584, United States

Cancer Care Northwest - Spokane SouthRecruiting

Spokane, Washington 99202, United States

Cancer Care Northwest-ValleyRecruiting

Spokane, Washington 99216, United States

Cancer Care Northwest-North SpokaneRecruiting

Spokane, Washington 99218, United States

PeaceHealth Southwest Medical CenterRecruiting

Vancouver, Washington 98664, United States

Providence Saint Mary Regional Cancer CenterRecruiting

Walla Walla, Washington 99362, United States

North Star Lodge Cancer Center at Yakima Valley Memorial HospitalSuspended

Yakima, Washington 98902, United States

Providence Regional Cancer System-YelmSuspended

Yelm, Washington 98597, United States

United Hospital CenterActive, not recruiting

Bridgeport, West Virginia 26330, United States

Edwards Comprehensive Cancer CenterRecruiting

Huntington, West Virginia 25701, United States

WVUH-Berkely Medical CenterActive, not recruiting

Martinsburg, West Virginia 25401, United States

West Virginia University HealthcareActive, not recruiting

Morgantown, West Virginia 26506, United States

Camden Clark Medical CenterActive, not recruiting

Parkersburg, West Virginia 26101, United States

Aurora Cancer Care-Southern Lakes VLCCRecruiting

Burlington, Wisconsin 53105, United States

Aurora Saint Luke's South ShoreRecruiting

Cudahy, Wisconsin 53110, United States

Marshfield Medical Center-EC Cancer CenterRecruiting

Eau Claire, Wisconsin 54701, United States

Aurora Health Care Germantown Health CenterRecruiting

Germantown, Wisconsin 53022, United States

Aurora Cancer Care-GraftonRecruiting

Grafton, Wisconsin 53024, United States

Aurora BayCare Medical CenterRecruiting

Green Bay, Wisconsin 54311, United States

Mercyhealth Hospital and Cancer Center - JanesvilleActive, not recruiting

Janesville, Wisconsin 53548, United States

Aurora Cancer Care-Kenosha SouthRecruiting

Kenosha, Wisconsin 53142, United States

Gundersen Lutheran Medical CenterRecruiting

La Crosse, Wisconsin 54601, United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterRecruiting

Madison, Wisconsin 53718, United States

University of Wisconsin Carbone Cancer Center - University HospitalRecruiting

Madison, Wisconsin 53792, United States

Aurora Bay Area Medical Group-MarinetteRecruiting

Marinette, Wisconsin 54143, United States

Marshfield Medical Center-MarshfieldRecruiting

Marshfield, Wisconsin 54449, United States

Aurora Cancer Care-MilwaukeeRecruiting

Milwaukee, Wisconsin 53209, United States

Aurora Saint Luke's Medical CenterRecruiting

Milwaukee, Wisconsin 53215, United States

Aurora Sinai Medical CenterRecruiting

Milwaukee, Wisconsin 53233, United States

Marshfield Medical Center - MinocquaRecruiting

Minocqua, Wisconsin 54548, United States

Vince Lombardi Cancer Clinic - OshkoshRecruiting

Oshkosh, Wisconsin 54904, United States

Aurora Cancer Care-RacineRecruiting

Racine, Wisconsin 53406, United States

Marshfield Medical Center-Rice LakeRecruiting

Rice Lake, Wisconsin 54868, United States

Vince Lombardi Cancer Clinic-SheboyganRecruiting

Sheboygan, Wisconsin 53081, United States

Marshfield Medical Center-River Region at Stevens PointRecruiting

Stevens Point, Wisconsin 54482, United States

Aurora Medical Center in SummitRecruiting

Summit, Wisconsin 53066, United States

Site Public ContactContact

ncorp@aurora.org414-302-2304

Vince Lombardi Cancer Clinic-Two RiversRecruiting

Two Rivers, Wisconsin 54241, United States

Aurora Cancer Care-Milwaukee WestRecruiting

Wauwatosa, Wisconsin 53226, United States

Aurora West Allis Medical CenterRecruiting

West Allis, Wisconsin 53227, United States

Marshfield Medical Center - WestonRecruiting

Weston, Wisconsin 54476, United States

Royal Columbian HospitalSuspended

New Westminster, British Columbia V3L 3W7, Canada

Juravinski Cancer Centre at Hamilton Health SciencesSuspended

Hamilton, Ontario L8V 5C2, Canada

Kingston Health Sciences CentreSuspended

Kingston, Ontario K7L 2V7, Canada

Odette Cancer Centre- Sunnybrook Health Sciences CentreSuspended

Toronto, Ontario M4N 3M5, Canada

Cancer Center-Metro Medical Center BayamonRecruiting

Bayamón, 00959-5060, Puerto Rico

Puerto Rico Hematology Oncology GroupRecruiting

Bayamón, 00961, Puerto Rico

HIMA San Pablo Oncologic HospitalSuspended

Caguas, 00726, Puerto Rico

Doctors Cancer CenterRecruiting

Manati, 00674, Puerto Rico

Instituto Oncologia Moderna PonceSuspended

Ponce, 00716, Puerto Rico

San Juan Community Oncology GroupRecruiting

San Juan, 00917, Puerto Rico

Primary Care Physician GroupSuspended

San Juan, 00920, Puerto Rico

Centro Comprensivo de Cancer de UPRRecruiting

San Juan, 00927, Puerto Rico

PROncologyRecruiting

San Juan, 00927, Puerto Rico

San Juan City HospitalRecruiting

San Juan, 00936, Puerto Rico

National Cancer Center-KoreaRecruiting

Goyang-si, Gyeonggi-do 410-769, South Korea

Yonsei University Health System-Severance HospitalRecruiting

Seoul, 120-752, South Korea