HRV will be modulated by conforming respiration and heart rate to optimal breathing patterns. The games are designed to guide subjects' physiology to a more optimal state for pain reduction using biofeedback. Resonant breathing is breathing that activates the coordinated function of oscillating body systems. This breathing increases your Heart Rate Variability. Greater Heart Rate Variability (a higher HRV score) at rest indicates better outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

The Craving Index questionnaire on the Flowly app assesses opioid cravings using 6 qualitatively scaled questions, ranging from 'none' (minimum score: 0) to 'the greatest possibility' (maximum score: 5 per question, total score: 30). Lower scores indicate less frequent opioid cravings, suggesting better outcomes. Measurements were assessed weekly, and the analysis focused on comparing scores between baseline and 8 weeks to evaluate changes in cravings between the two groups.

The investigators used the PROMIS Physical Function Short Form T-score to assess key patient-centered outcomes related to physical function. This assessment includes 4 physical function-related questions, each scored on a 5-point Likert scale (1 = unable to do, 5 = without any difficulty). The raw total score ranges from a minimum of 4 to a maximum of 20.

Responses were converted to T-scores, where the mean in the general population is 50 with a standard deviation of 10. Higher T-scores indicate better physical function, while lower T-scores suggest worse physical function. Clinically relevant thresholds may indicate that lower scores are associated with greater physical disability.

Measurements were conducted at baseline and Week 8, with the analysis focused on comparing changes in physical function between the two groups.

The investigators used the PROMIS Fatigue Short Form T-score to assess key patient-centered outcomes related to fatigue. This assessment includes 4 fatigue-related questions, each scored on a 5-point Likert scale (1 = not at all, 5 = very much). The raw total score ranges from a minimum of 4 to a maximum of 20.

Responses were converted to T-scores, where the mean in the general population is 50 with a standard deviation of 10. Higher T-scores indicate greater fatigue, while lower T-scores suggest less fatigue, which reflects better outcomes. Clinically relevant thresholds suggest that elevated T-scores may indicate increased fatigue severity.

Measurements were conducted at baseline and Week 8, with the analysis focused on comparing changes in fatigue levels between the two groups.

The investigators used the PROMIS Pain Interference Short Form to assess how pain impacts daily activities. This measure includes 5 pain-related questions, each scored on a 5-point Likert scale (1 = not at all, 5 = very much). The raw total score (range: 5 to 25) was converted to a standardized T-score (mean = 50, SD = 10).

Higher T-scores indicate greater pain interference, while lower T-scores suggest less interference (better outcomes). A T-score of 60+ may indicate clinically significant pain interference, while 40 or lower suggests minimal interference.

Measurements were conducted over the study, with scores compared between baseline and 8 weeks to assess changes in pain interference.

The investigators used the PROMIS Pain Intensity Item to assess patients' self-reported pain levels. This measure consists of one question, scored on an 11-point Likert scale (0 = no pain, 10 = worst imaginable pain). The raw score was converted to a standardized T-score (mean = 50, SD = 10).

Higher T-scores indicate greater pain intensity, while lower T-scores suggest less pain (better outcomes). A T-score of 60+ may indicate clinically significant pain, while 40 or lower suggests mild or minimal pain.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in pain intensity.

The investigators used the PROMIS Sleep Disturbance Short Form to assess patient-reported sleep difficulties. This measure includes 4 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater sleep disturbance (worse outcomes), while lower T-scores suggest better sleep quality. A T-score of 60+ may indicate clinically significant sleep disturbance, while 40 or lower suggests minimal issues.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in sleep disturbance.

The investigators used the PROMIS Ability to Participate in Social Roles and Activities Short Form to assess social participation. This measure includes 4 items, each rated on a 5-point Likert scale (1 = never, 5 = always). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater ability to engage in social roles and activities (better outcomes), while lower scores suggest more social restrictions. A T-score below 40 may indicate clinically significant limitations in social participation.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in social participation.

The investigators used the PROMIS Depression Short Form to assess depressive symptoms. This measure includes 4 items, each rated on a 5-point Likert scale (1 = never, 5 = always). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater levels of depression (worse outcomes), while lower scores reflect fewer depressive symptoms. A T-score above 60 suggests clinically significant depression, while a T-score below 50 reflects better mental health relative to the general population.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in depressive symptoms.

The investigators used the PROMIS Anxiety Short Form to assess anxiety symptoms. This measure includes 4 items, each rated on a 5-point Likert scale (1 = never, 5 = always). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater levels of anxiety (worse outcomes), while lower scores reflect reduced anxiety symptoms. A T-score above 60 suggests clinically significant anxiety, while a T-score below 50 reflects better emotional health relative to the general population.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in anxiety symptoms.

The investigators used the PROMIS Emotional Support Short Form to assess patient-centered outcomes related to loneliness. This measure includes 4 items, each rated on a 5-point Likert scale (1 = never, 5 = always). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater loneliness (worse outcomes), while lower scores suggest better emotional support. A T-score above 60 suggests clinically significant loneliness, while a T-score below 50 reflects better perceived emotional support relative to the general population.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in loneliness.

The investigators will use the PainDetect Questionnaire, a validated tool to assess patients' perceptions and feelings about pain. The questionnaire includes 15 multiple-choice questions and a drawing of localized pain, yielding a total score that ranges from 0 (minimum) to 38 (maximum). Lower scores indicate less neuropathic pain and suggest better outcomes.

The investigators will use the PainDetect Questionnaire, a validated tool to assess patients' perceptions and feelings about pain. The questionnaire includes 15 multiple-choice questions and a drawing of localized pain, yielding a total score that ranges from 0 (minimum) to 38 (maximum). Lower scores indicate less neuropathic pain and suggest better outcomes.

The investigators will use the PainDetect Questionnaire, a validated tool to assess patients' perceptions and feelings about pain. The questionnaire includes 15 multiple-choice questions and a drawing of localized pain, yielding a total score that ranges from 0 (minimum) to 38 (maximum). Lower scores indicate less neuropathic pain and suggest better outcomes.

The investigators will measure subjects' salivary cortisol levels using validated laboratory techniques. Cortisol levels are reported in micrograms per deciliter (mcg/dL) and have no predefined minimum or maximum values. Lower cortisol levels indicate better outcomes.

The investigators will measure subjects' salivary cortisol levels using validated laboratory techniques. Cortisol levels are reported in micrograms per deciliter (mcg/dL) and have no predefined minimum or maximum values. Lower cortisol levels indicate better outcomes.

The investigators will measure subjects' salivary cortisol levels using validated laboratory techniques. Cortisol levels are reported in micrograms per deciliter (mcg/dL) and have no predefined minimum or maximum values. Lower cortisol levels indicate better outcomes.

The amount of opiates found in the urine of each subject will be recorded throughout the study. The lower the detected morphine milligram equivalent [MME], the better the outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

The amount of opiates found in the urine of each subject will be recorded throughout the study. The lower the detected morphine milligram equivalent [MME], the better the outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

The amount of opiates found in the urine of each subject will be recorded throughout the study. The lower the detected morphine milligram equivalent [MME], the better the outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

The Subjective Opiate Withdrawal Scale (SOWS) will assess subjects' withdrawal symptoms using 16 multiple-choice questions, each scored from 0 (not at all) to 4 (extremely). The total score ranges from a minimum of 0 to a maximum of 64. Lower scores indicate better outcomes and fewer withdrawal symptoms.

The Subjective Opiate Withdrawal Scale (SOWS) will assess subjects' withdrawal symptoms using 16 multiple-choice questions, each scored from 0 (not at all) to 4 (extremely). The total score ranges from a minimum of 0 to a maximum of 64. Lower scores indicate better outcomes and fewer withdrawal symptoms.

The Subjective Opiate Withdrawal Scale (SOWS) will assess subjects' withdrawal symptoms using 16 multiple-choice questions, each scored from 0 (not at all) to 4 (extremely). The total score ranges from a minimum of 0 to a maximum of 64. Lower scores indicate better outcomes and fewer withdrawal symptoms.

The Pain Catastrophizing Scale (PCS) will assess subjects' beliefs about pain using 13 multiple-choice questions, each scored from 1 (not at all) to 5 (all the time). The total score ranges from a minimum of 13 to a maximum of 65. Lower scores indicate better outcomes and less catastrophizing about pain.

The Pain Catastrophizing Scale (PCS) will assess subjects' beliefs about pain using 13 multiple-choice questions, each scored from 1 (not at all) to 5 (all the time). The total score ranges from a minimum of 13 to a maximum of 65. Lower scores indicate better outcomes and less catastrophizing about pain.

The Pain Catastrophizing Scale (PCS) will assess subjects' beliefs about pain using 13 multiple-choice questions, each scored from 1 (not at all) to 5 (all the time). The total score ranges from a minimum of 13 to a maximum of 65. Lower scores indicate better outcomes and less catastrophizing about pain.

The Treatment Expectancy Short Form assesses subjects' expectations and confidence in their treatment using 6 items, each scored on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater treatment expectancy, suggesting more positive beliefs about treatment efficacy. Lower T-scores reflect greater skepticism or uncertainty. A T-score above 60 may indicate high confidence in treatment, while a T-score below 40 suggests low expectancy.

The Treatment Expectancy Short Form assesses subjects' expectations and confidence in their treatment using 6 items, each scored on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater treatment expectancy, suggesting more positive beliefs about treatment efficacy. Lower T-scores reflect greater skepticism or uncertainty. A T-score above 60 may indicate high confidence in treatment, while a T-score below 40 suggests low expectancy.

The Treatment Expectancy Short Form evaluates subjects' expectations and confidence in their treatment using 6 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater treatment expectancy, suggesting more positive beliefs about treatment efficacy. Lower T-scores reflect greater skepticism or uncertainty. A T-score above 60 may indicate high confidence in treatment, while a T-score below 40 suggests low expectancy.

The Positive Outlook Short Form measures subjects' perceptions and feelings about the future using 6 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater optimism and a more positive outlook, suggesting better psychological well-being. Lower T-scores reflect greater pessimism or concerns about the future. A T-score above 60 may indicate high optimism, while a T-score below 40 suggests low optimism or increased negative expectations.

The Positive Outlook Short Form measures subjects' perceptions and feelings about the future using 6 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater optimism and a more positive outlook, suggesting better psychological well-being. Lower T-scores reflect greater pessimism or concerns about the future. A T-score above 60 may indicate high optimism, while a T-score below 40 suggests low optimism or increased negative expectations.

The Positive Outlook Short Form evaluates subjects' perceptions and expectations about the future using 6 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater optimism and a more positive outlook, suggesting better psychological well-being. Lower T-scores reflect greater pessimism or concerns about the future. A T-score above 60 may indicate high optimism, while a T-score below 40 suggests low optimism or increased negative expectations.

The Current Opioid Misuse Measure (COMM) questionnaire assesses recent behaviors using 17 multiple-choice questions, with scores ranging from a minimum of 0 to a maximum of 68. Lower scores suggest better outcomes and less likelihood of opioid misuse.

The Current Opioid Misuse Measure (COMM) questionnaire assesses recent behaviors using 17 multiple-choice questions, with scores ranging from a minimum of 0 to a maximum of 68. Lower scores suggest better outcomes and less likelihood of opioid misuse.

The Current Opioid Misuse Measure (COMM) questionnaire assesses recent behaviors using 17 multiple-choice questions, with scores ranging from a minimum of 0 to a maximum of 68. Lower scores suggest better outcomes and less likelihood of opioid misuse.

The Tellegen Absorption Scale (TAS) assesses an individual's ability to become deeply engaged in a task or an aspect of their environment. The scale consists of 34 true-or-false items, where each "true" response is scored as 1, and each "false" response is scored as 0.

The total score ranges from 0 to 34, with higher scores indicating a greater capacity for absorption and immersive engagement. This measure evaluates attentional focus and deep engagement in activities, which may be relevant for assessing response to virtual reality interventions.

The Tellegen Absorption Scale (TAS) assesses an individual's ability to become deeply engaged in a task or an aspect of their environment. The scale consists of 34 true-or-false items, where each "true" response is scored as 1, and each "false" response is scored as 0.

The total score ranges from 0 to 34, with higher scores indicating a greater capacity for absorption and immersive engagement. This measure evaluates attentional focus and deep engagement in activities, which may be relevant for assessing response to virtual reality interventions.

The Tellegen Absorption Scale (TAS) assesses an individual's ability to become deeply engaged in a task or an aspect of their environment. The scale consists of 34 true-or-false items, where each "true" response is scored as 1, and each "false" response is scored as 0.

The total score ranges from 0 to 34, with higher scores indicating a greater capacity for absorption and immersive engagement. This measure evaluates attentional focus and deep engagement in activities, which may be relevant for assessing response to virtual reality interventions.

Subjects rated their current pain level using the 0-10 Visual Analog Scale (VAS) within the Flowly app, where 0 represents no pain and 10 represents the worst imaginable pain. Pain scores were recorded immediately before and after each VR session, which took place daily throughout the study.

For analysis, pain scores were assessed at baseline and at Week 8. The Week 8 value represents the average of daily post-session scores recorded during the final week of the study. The change in pain levels was calculated by comparing the baseline value to the Week 8 average.

Higher scores indicate greater pain intensity, while lower scores suggest better outcomes (i.e., pain reduction).

Subjects rated their current anxiety level using the 0-10 Visual Analog Scale (VAS) within the Flowly app, where 0 represents no anxiety and 10 represents the worst imaginable anxiety. Anxiety scores were recorded immediately before and after each VR session, which took place daily throughout the study.

For analysis, anxiety scores were assessed at baseline and at Week 8. The Week 8 value represents the average of daily post-session scores recorded during the final week of the study. The change in anxiety levels was calculated by comparing the baseline value to the Week 8 average.

Higher scores indicate greater anxiety levels, while lower scores suggest better outcomes (i.e., anxiety reduction).

Subjects rated their current depression level using the 0-10 Visual Analog Scale (VAS) within the Flowly app, where 0 represents no depression and 10 represents the worst imaginable depression. Depression scores were recorded immediately before and after each VR session, which took place daily throughout the study.

For analysis, depression scores were assessed at baseline and at Week 8. The Week 8 value represents the average of daily post-session scores recorded during the final week of the study. The change in depression levels was calculated by comparing the baseline value to the Week 8 average.

Higher scores indicate greater depression levels, while lower scores suggest better outcomes (i.e., depression reduction).

Ten patients will be randomly assigned to receive their current opioid prescription and tapering guidelines, as standard of care.

Total of all reporting groups

The amount and dosing of opioid medications taken by each subject will be recorded throughout the study. The lower the average daily morphine milligram equivalent [MME], the better the outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

The amount and dosing of opioid medications taken by each subject will be recorded throughout the study. The lower the average daily morphine milligram equivalent [MME], the better the outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

HRV will be modulated by conforming respiration and heart rate to optimal breathing patterns. The games are designed to guide subjects' physiology to a more optimal state for pain reduction using biofeedback. Resonant breathing is breathing that activates the coordinated function of oscillating body systems. This breathing increases your Heart Rate Variability. Greater Heart Rate Variability (a higher HRV score) at rest indicates better outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

HRV data were not collected due to a malfunction in the Flowly app, which was in beta testing during the study. The app was intended to collect HRV via a paired biometric sensor, but it failed to reliably communicate with the device. As a result, HRV measurements were not transmitted or stored, and no usable data were available for analysis.

The Craving Index questionnaire on the Flowly app assesses opioid cravings using 6 qualitatively scaled questions, ranging from 'none' (minimum score: 0) to 'the greatest possibility' (maximum score: 5 per question, total score: 30). Lower scores indicate less frequent opioid cravings, suggesting better outcomes. Measurements were assessed weekly, and the analysis focused on comparing scores between baseline and 8 weeks to evaluate changes in cravings between the two groups.

The investigators used the PROMIS Physical Function Short Form T-score to assess key patient-centered outcomes related to physical function. This assessment includes 4 physical function-related questions, each scored on a 5-point Likert scale (1 = unable to do, 5 = without any difficulty). The raw total score ranges from a minimum of 4 to a maximum of 20.

Responses were converted to T-scores, where the mean in the general population is 50 with a standard deviation of 10. Higher T-scores indicate better physical function, while lower T-scores suggest worse physical function. Clinically relevant thresholds may indicate that lower scores are associated with greater physical disability.

Measurements were conducted at baseline and Week 8, with the analysis focused on comparing changes in physical function between the two groups.

The investigators used the PROMIS Fatigue Short Form T-score to assess key patient-centered outcomes related to fatigue. This assessment includes 4 fatigue-related questions, each scored on a 5-point Likert scale (1 = not at all, 5 = very much). The raw total score ranges from a minimum of 4 to a maximum of 20.

Responses were converted to T-scores, where the mean in the general population is 50 with a standard deviation of 10. Higher T-scores indicate greater fatigue, while lower T-scores suggest less fatigue, which reflects better outcomes. Clinically relevant thresholds suggest that elevated T-scores may indicate increased fatigue severity.

Measurements were conducted at baseline and Week 8, with the analysis focused on comparing changes in fatigue levels between the two groups.

The investigators used the PROMIS Pain Interference Short Form to assess how pain impacts daily activities. This measure includes 5 pain-related questions, each scored on a 5-point Likert scale (1 = not at all, 5 = very much). The raw total score (range: 5 to 25) was converted to a standardized T-score (mean = 50, SD = 10).

Higher T-scores indicate greater pain interference, while lower T-scores suggest less interference (better outcomes). A T-score of 60+ may indicate clinically significant pain interference, while 40 or lower suggests minimal interference.

Measurements were conducted over the study, with scores compared between baseline and 8 weeks to assess changes in pain interference.

The investigators used the PROMIS Pain Intensity Item to assess patients' self-reported pain levels. This measure consists of one question, scored on an 11-point Likert scale (0 = no pain, 10 = worst imaginable pain). The raw score was converted to a standardized T-score (mean = 50, SD = 10).

Higher T-scores indicate greater pain intensity, while lower T-scores suggest less pain (better outcomes). A T-score of 60+ may indicate clinically significant pain, while 40 or lower suggests mild or minimal pain.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in pain intensity.

The investigators used the PROMIS Sleep Disturbance Short Form to assess patient-reported sleep difficulties. This measure includes 4 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater sleep disturbance (worse outcomes), while lower T-scores suggest better sleep quality. A T-score of 60+ may indicate clinically significant sleep disturbance, while 40 or lower suggests minimal issues.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in sleep disturbance.

The investigators used the PROMIS Ability to Participate in Social Roles and Activities Short Form to assess social participation. This measure includes 4 items, each rated on a 5-point Likert scale (1 = never, 5 = always). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater ability to engage in social roles and activities (better outcomes), while lower scores suggest more social restrictions. A T-score below 40 may indicate clinically significant limitations in social participation.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in social participation.

The investigators used the PROMIS Depression Short Form to assess depressive symptoms. This measure includes 4 items, each rated on a 5-point Likert scale (1 = never, 5 = always). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater levels of depression (worse outcomes), while lower scores reflect fewer depressive symptoms. A T-score above 60 suggests clinically significant depression, while a T-score below 50 reflects better mental health relative to the general population.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in depressive symptoms.

The investigators used the PROMIS Anxiety Short Form to assess anxiety symptoms. This measure includes 4 items, each rated on a 5-point Likert scale (1 = never, 5 = always). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater levels of anxiety (worse outcomes), while lower scores reflect reduced anxiety symptoms. A T-score above 60 suggests clinically significant anxiety, while a T-score below 50 reflects better emotional health relative to the general population.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in anxiety symptoms.

The investigators used the PROMIS Emotional Support Short Form to assess patient-centered outcomes related to loneliness. This measure includes 4 items, each rated on a 5-point Likert scale (1 = never, 5 = always). The raw score (range: 4 to 20) was converted to a T-score (mean = 50, SD = 10).

Higher T-scores indicate greater loneliness (worse outcomes), while lower scores suggest better emotional support. A T-score above 60 suggests clinically significant loneliness, while a T-score below 50 reflects better perceived emotional support relative to the general population.

Measurements were conducted throughout the study, with scores compared between baseline and 8 weeks to assess changes in loneliness.

The investigators will use the PainDetect Questionnaire, a validated tool to assess patients' perceptions and feelings about pain. The questionnaire includes 15 multiple-choice questions and a drawing of localized pain, yielding a total score that ranges from 0 (minimum) to 38 (maximum). Lower scores indicate less neuropathic pain and suggest better outcomes.

The investigators will use the PainDetect Questionnaire, a validated tool to assess patients' perceptions and feelings about pain. The questionnaire includes 15 multiple-choice questions and a drawing of localized pain, yielding a total score that ranges from 0 (minimum) to 38 (maximum). Lower scores indicate less neuropathic pain and suggest better outcomes.

The investigators will use the PainDetect Questionnaire, a validated tool to assess patients' perceptions and feelings about pain. The questionnaire includes 15 multiple-choice questions and a drawing of localized pain, yielding a total score that ranges from 0 (minimum) to 38 (maximum). Lower scores indicate less neuropathic pain and suggest better outcomes.

The investigators will measure subjects' salivary cortisol levels using validated laboratory techniques. Cortisol levels are reported in micrograms per deciliter (mcg/dL) and have no predefined minimum or maximum values. Lower cortisol levels indicate better outcomes.

The investigators will measure subjects' salivary cortisol levels using validated laboratory techniques. Cortisol levels are reported in micrograms per deciliter (mcg/dL) and have no predefined minimum or maximum values. Lower cortisol levels indicate better outcomes.

Data were not collected at Week 4 because salivary cortisol levels were only measured at baseline (Week 0) and the study endpoint (Week 8). No data exist for this time point.

The investigators will measure subjects' salivary cortisol levels using validated laboratory techniques. Cortisol levels are reported in micrograms per deciliter (mcg/dL) and have no predefined minimum or maximum values. Lower cortisol levels indicate better outcomes.

The amount of opiates found in the urine of each subject will be recorded throughout the study. The lower the detected morphine milligram equivalent [MME], the better the outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

Urine drug screen data were not collected due to two key barriers: (1) the clinical personnel required to administer the tests were not consistently available during study visits, and (2) the cost of performing quantitative urine drug screens for each participant was beyond the scope of the study's budget. As a result, no data are available for this outcome.

The amount of opiates found in the urine of each subject will be recorded throughout the study. The lower the detected morphine milligram equivalent [MME], the better the outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

Urine drug screen data were not collected due to two key barriers: (1) the clinical personnel required to administer the tests were not consistently available during study visits, and (2) the cost of performing quantitative urine drug screens for each participant was beyond the scope of the study's budget. As a result, no data are available for this outcome.

The amount of opiates found in the urine of each subject will be recorded throughout the study. The lower the detected morphine milligram equivalent [MME], the better the outcomes. Outcomes will be measured over the span of the study and compared between the two groups.

Urine drug screen data were not collected due to two key barriers: (1) the clinical personnel required to administer the tests were not consistently available during study visits, and (2) the cost of performing quantitative urine drug screens for each participant was beyond the scope of the study's budget. As a result, no data are available for this outcome.

The Subjective Opiate Withdrawal Scale (SOWS) will assess subjects' withdrawal symptoms using 16 multiple-choice questions, each scored from 0 (not at all) to 4 (extremely). The total score ranges from a minimum of 0 to a maximum of 64. Lower scores indicate better outcomes and fewer withdrawal symptoms.

The Subjective Opiate Withdrawal Scale (SOWS) will assess subjects' withdrawal symptoms using 16 multiple-choice questions, each scored from 0 (not at all) to 4 (extremely). The total score ranges from a minimum of 0 to a maximum of 64. Lower scores indicate better outcomes and fewer withdrawal symptoms.

The Subjective Opiate Withdrawal Scale (SOWS) will assess subjects' withdrawal symptoms using 16 multiple-choice questions, each scored from 0 (not at all) to 4 (extremely). The total score ranges from a minimum of 0 to a maximum of 64. Lower scores indicate better outcomes and fewer withdrawal symptoms.

The Pain Catastrophizing Scale (PCS) will assess subjects' beliefs about pain using 13 multiple-choice questions, each scored from 1 (not at all) to 5 (all the time). The total score ranges from a minimum of 13 to a maximum of 65. Lower scores indicate better outcomes and less catastrophizing about pain.

The Pain Catastrophizing Scale (PCS) will assess subjects' beliefs about pain using 13 multiple-choice questions, each scored from 1 (not at all) to 5 (all the time). The total score ranges from a minimum of 13 to a maximum of 65. Lower scores indicate better outcomes and less catastrophizing about pain.

The Pain Catastrophizing Scale (PCS) will assess subjects' beliefs about pain using 13 multiple-choice questions, each scored from 1 (not at all) to 5 (all the time). The total score ranges from a minimum of 13 to a maximum of 65. Lower scores indicate better outcomes and less catastrophizing about pain.

The Treatment Expectancy Short Form assesses subjects' expectations and confidence in their treatment using 6 items, each scored on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater treatment expectancy, suggesting more positive beliefs about treatment efficacy. Lower T-scores reflect greater skepticism or uncertainty. A T-score above 60 may indicate high confidence in treatment, while a T-score below 40 suggests low expectancy.

The Treatment Expectancy Short Form assesses subjects' expectations and confidence in their treatment using 6 items, each scored on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater treatment expectancy, suggesting more positive beliefs about treatment efficacy. Lower T-scores reflect greater skepticism or uncertainty. A T-score above 60 may indicate high confidence in treatment, while a T-score below 40 suggests low expectancy.

The Treatment Expectancy Short Form evaluates subjects' expectations and confidence in their treatment using 6 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater treatment expectancy, suggesting more positive beliefs about treatment efficacy. Lower T-scores reflect greater skepticism or uncertainty. A T-score above 60 may indicate high confidence in treatment, while a T-score below 40 suggests low expectancy.

The Positive Outlook Short Form measures subjects' perceptions and feelings about the future using 6 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater optimism and a more positive outlook, suggesting better psychological well-being. Lower T-scores reflect greater pessimism or concerns about the future. A T-score above 60 may indicate high optimism, while a T-score below 40 suggests low optimism or increased negative expectations.

The Positive Outlook Short Form measures subjects' perceptions and feelings about the future using 6 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater optimism and a more positive outlook, suggesting better psychological well-being. Lower T-scores reflect greater pessimism or concerns about the future. A T-score above 60 may indicate high optimism, while a T-score below 40 suggests low optimism or increased negative expectations.

The Positive Outlook Short Form evaluates subjects' perceptions and expectations about the future using 6 items, each rated on a 5-point Likert scale (1 = not at all, 5 = very much). The raw score (range: 6 to 30) is converted to a T-score (mean = 50, SD = 10) for standardized interpretation.

Higher T-scores indicate greater optimism and a more positive outlook, suggesting better psychological well-being. Lower T-scores reflect greater pessimism or concerns about the future. A T-score above 60 may indicate high optimism, while a T-score below 40 suggests low optimism or increased negative expectations.

The Current Opioid Misuse Measure (COMM) questionnaire assesses recent behaviors using 17 multiple-choice questions, with scores ranging from a minimum of 0 to a maximum of 68. Lower scores suggest better outcomes and less likelihood of opioid misuse.

The Current Opioid Misuse Measure (COMM) questionnaire assesses recent behaviors using 17 multiple-choice questions, with scores ranging from a minimum of 0 to a maximum of 68. Lower scores suggest better outcomes and less likelihood of opioid misuse.

The Current Opioid Misuse Measure (COMM) questionnaire assesses recent behaviors using 17 multiple-choice questions, with scores ranging from a minimum of 0 to a maximum of 68. Lower scores suggest better outcomes and less likelihood of opioid misuse.

The Tellegen Absorption Scale (TAS) assesses an individual's ability to become deeply engaged in a task or an aspect of their environment. The scale consists of 34 true-or-false items, where each "true" response is scored as 1, and each "false" response is scored as 0.

The total score ranges from 0 to 34, with higher scores indicating a greater capacity for absorption and immersive engagement. This measure evaluates attentional focus and deep engagement in activities, which may be relevant for assessing response to virtual reality interventions.

The Tellegen Absorption Scale (TAS) assesses an individual's ability to become deeply engaged in a task or an aspect of their environment. The scale consists of 34 true-or-false items, where each "true" response is scored as 1, and each "false" response is scored as 0.

The total score ranges from 0 to 34, with higher scores indicating a greater capacity for absorption and immersive engagement. This measure evaluates attentional focus and deep engagement in activities, which may be relevant for assessing response to virtual reality interventions.

The Tellegen Absorption Scale (TAS) assesses an individual's ability to become deeply engaged in a task or an aspect of their environment. The scale consists of 34 true-or-false items, where each "true" response is scored as 1, and each "false" response is scored as 0.

The total score ranges from 0 to 34, with higher scores indicating a greater capacity for absorption and immersive engagement. This measure evaluates attentional focus and deep engagement in activities, which may be relevant for assessing response to virtual reality interventions.

Subjects rated their current pain level using the 0-10 Visual Analog Scale (VAS) within the Flowly app, where 0 represents no pain and 10 represents the worst imaginable pain. Pain scores were recorded immediately before and after each VR session, which took place daily throughout the study.

For analysis, pain scores were assessed at baseline and at Week 8. The Week 8 value represents the average of daily post-session scores recorded during the final week of the study. The change in pain levels was calculated by comparing the baseline value to the Week 8 average.

Higher scores indicate greater pain intensity, while lower scores suggest better outcomes (i.e., pain reduction).

Subjects rated their current anxiety level using the 0-10 Visual Analog Scale (VAS) within the Flowly app, where 0 represents no anxiety and 10 represents the worst imaginable anxiety. Anxiety scores were recorded immediately before and after each VR session, which took place daily throughout the study.

For analysis, anxiety scores were assessed at baseline and at Week 8. The Week 8 value represents the average of daily post-session scores recorded during the final week of the study. The change in anxiety levels was calculated by comparing the baseline value to the Week 8 average.

Higher scores indicate greater anxiety levels, while lower scores suggest better outcomes (i.e., anxiety reduction).

Subjects rated their current depression level using the 0-10 Visual Analog Scale (VAS) within the Flowly app, where 0 represents no depression and 10 represents the worst imaginable depression. Depression scores were recorded immediately before and after each VR session, which took place daily throughout the study.

For analysis, depression scores were assessed at baseline and at Week 8. The Week 8 value represents the average of daily post-session scores recorded during the final week of the study. The change in depression levels was calculated by comparing the baseline value to the Week 8 average.

Higher scores indicate greater depression levels, while lower scores suggest better outcomes (i.e., depression reduction).

Ten patients will be randomly assigned to receive their current opioid prescription and tapering guidelines, as standard of care.